Editing Cerebrospinal fluid (section)

===CSF drug delivery===
CSF drug delivery refers to a number of methods designed to administer therapeutic agents directly into the CSF, bypassing the BBB to achieve higher drug concentrations in the CNS. This technique is particularly beneficial for treating neurological disorders such as brain tumors, infections, and neurodegenerative diseases. Intrathecal injection, where drugs are injected directly into the CSF via the lumbar region, and intracerebroventricular injection, targeting the brain's ventricles, are common approaches. These methods ensure that drugs can reach the CNS more effectively than systemic administration, potentially improving therapeutic outcomes and reducing systemic side effects. Advances in this field are driven by ongoing research into novel delivery systems and drug formulations, enhancing the precision and efficacy of treatments.
Intrathecal pseudodelivery refers to a particular drug delivery method where the therapeutic agent is introduced into a reservoir connected to the intrathecal space, rather than being released into the CSF and distributed throughout the CNS. In this approach, the drug interacts with its target within the reservoir, allowing for changing the composition of the CSF without systemic release. This method can be advantageous for maximizing efficacy and minimizing systemic side effects. 
<ref>{{Cite journal |last1=Sun |first1=Wujin |last2=Gu |first2=Zhen |date=2016-03-03 |title=ATP-Responsive Drug Delivery Systems |journal=Expert Opinion on Drug Delivery |language=en |volume=13 |issue=3 |pages=311–314 |doi=10.1517/17425247.2016.1140147 |issn=1742-5247 |pmc=4998835 |pmid=26745457}}</ref>