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===Unisexual reproduction=== Unisexual female [[mole salamander]]s (genus Ambystoma) are common in the Great Lakes region of North America.<ref>Bogart JP, Bi K, Fu J, Noble DW, Niedzwiecki J. Unisexual salamanders (genus Ambystoma) present a new reproductive mode for eukaryotes. Genome. 2007 Feb;50(2):119-36. doi: 10.1139/g06-152. PMID 17546077</ref> These salamanders are the oldest known unisexual vertebrate lineage, having emerged about 5 million years ago.<ref name="Gibbs2016">Gibbs HL, Denton RD. Cryptic sex? Estimates of genome exchange in unisexual mole salamanders (Ambystoma sp.). Mol Ecol. 2016 Jun;25(12):2805-15. doi: 10.1111/mec.13662. Epub 2016 May 21. PMID 27100619</ref> [[Genome]] exchange can sometimes occur between the unisexual female Ambystoma and males from sympatric sexual species.<ref name = Gibbs2016/>
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