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===Specialized methods=== Many methods exist for the preparation of amines, many of these methods being rather specialized. {| class="wikitable sortable" style="background:white; float:center; margin:0 1em;" |- ! style="width:200px;"|Reaction name !! Substrate !! class="unsortable" | Comment |- |valign=top| [[Staudinger reduction]] |[[Organic azide]] | This reaction also takes place with a reducing agent such as [[lithium aluminium hydride]]. |- |valign=top| [[Schmidt reaction]] |valign=top|[[Carboxylic acid]] | |- |valign=top| [[Aza-Baylis–Hillman reaction]] |valign=top|[[Imine]] | Synthesis of allylic amines |- |valign=top| [[Birch reduction]] |valign=top| [[Imine]] | Useful for reactions that trap unstable imine intermediates, such as [[Grignard reaction]]s with [[nitrile]]s.<ref>{{cite journal|last1=Weiberth|first1=Franz J.|last2=Hall|first2=Stan S.|title=Tandem alkylation-reduction of nitriles. Synthesis of branched primary amines|journal=Journal of Organic Chemistry|date=1986|volume=51|issue=26|pages=5338–5341|doi=10.1021/jo00376a053}}</ref> |- |valign=top| [[Hofmann rearrangement|Hofmann degradation]] |valign=top|[[Amide]] | This reaction is valid for preparation of primary amines only. Gives good yields of primary amines uncontaminated with other amines. |- |valign=top| [[Hofmann elimination]] |valign=top| [[Quaternary ammonium salt]] |Upon treatment with strong base |- |valign=top| [[Leuckart reaction]] |valign=top| [[Ketone]]s and [[aldehyde]]s | [[Reductive amination]] with [[formic acid]] and [[ammonia]] via an [[imine]] intermediate |- |valign=top| [[Hofmann–Löffler reaction]] |valign=top| [[Haloamine]] | |- |valign=top| [[Eschweiler–Clarke reaction]] |valign=top| Amine | [[Reductive amination]] with [[formic acid]] and [[formaldehyde]] via an [[imine]] intermediate |}
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