Editing Allergy (section)

===Late-phase response===
After the chemical mediators of the acute response subside, late-phase responses can often occur. This is due to the migration of other [[leukocyte]]s such as [[neutrophil]]s, [[lymphocyte]]s, [[eosinophil]]s, and [[macrophage]]s to the initial site. The reaction is usually seen 2–24 hours after the original reaction.<ref name="Effector and potential immunoregulatory roles of mast cells in IgE-associated acquired immune responses"/> Cytokines from mast cells may play a role in the persistence of long-term effects. Late-phase responses seen in asthma are slightly different from those seen in other allergic responses, although they are still caused by release of mediators from eosinophils and are still dependent on activity of T<sub>H</sub>2 cells.<ref name="Th2 cytokines in the asthma late-phase response"/>