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== History == A molecule that allows the genetic material to be realized as a protein was first hypothesized by [[François Jacob]] and [[Jacques Monod]]. [[Severo Ochoa]] won a [[Nobel Prize in Physiology or Medicine]] in 1959 for developing a process for synthesizing RNA ''[[in vitro]]'' with [[polynucleotide phosphorylase]], which was useful for cracking the [[genetic code]]. RNA synthesis by [[RNA polymerase]] was established ''in vitro'' by several laboratories by 1965; however, the RNA synthesized by these enzymes had properties that suggested the existence of an additional factor needed to terminate transcription correctly.{{citation needed|date=January 2011}} [[Roger D. Kornberg]] won the 2006 [[Nobel Prize in Chemistry]] "for his studies of the molecular basis of [[eukaryotic transcription]]".<ref>{{cite web|url=http://nobelprize.org/nobel_prizes/chemistry/laureates/2006/|title=Chemistry 2006|work=Nobel Foundation|access-date=March 29, 2007|url-status=live|archive-url=https://web.archive.org/web/20070315222401/http://nobelprize.org/nobel_prizes/chemistry/laureates/2006/|archive-date=March 15, 2007}}</ref>
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