Editing Sepsis (section)

=== Blood products ===
The Surviving Sepsis Campaign recommended [[packed red blood cells]] transfusion for [[hemoglobin]] levels below 70 g/L if there is no [[myocardial ischemia]], [[hypoxemia]], or acute bleeding.<ref name= "SSC–G2016"/> In a 2014 trial, blood transfusions to keep target hemoglobin above 70 or 90 g/L did not make any difference to survival rates; meanwhile, those with a lower threshold of transfusion received fewer transfusions in total.<ref name=Holst2014/> [[Erythropoietin]] is not recommended in the treatment of anemia with septic shock because it may precipitate blood clotting events. [[Fresh frozen plasma]] transfusion usually does not correct the underlying clotting abnormalities before a planned surgical procedure. However, platelet transfusion is suggested for platelet counts below (10 × 10<sup>9</sup>/L) without any risk of bleeding, or (20 × 10<sup>9</sup>/L) with a high risk of bleeding, or (50 × 10<sup>9</sup>/L) with active bleeding, before planned surgery or an invasive procedure.<ref name= "SSC–G2016"/> IV immunoglobulin is not recommended because its beneficial effects are uncertain.<ref name= "SSC–G2016"/> Monoclonal and polyclonal preparations of [[intravenous immunoglobulin|intravenous immunoglobulin (IVIG)]] do not lower the rate of death in newborns and adults with sepsis.<ref name="Alejandria2013"/> Evidence for the use of [[immunoglobulin M|IgM]]-enriched polyclonal preparations of IVIG is inconsistent.<ref name="Alejandria2013"/> On the other hand, the use of [[antithrombin#Medical uses|antithrombin]] to treat [[disseminated intravascular coagulation]] is also not useful. Meanwhile, the blood purification technique (such as [[hemoperfusion]], plasma filtration, and coupled plasma filtration adsorption) to remove inflammatory mediators and bacterial toxins from the blood also does not demonstrate any survival benefit for septic shock.<ref name= "SSC–G2016"/>