Editing Scabies (section)

=== Ivermectin ===
Oral [[ivermectin]] is effective in eradicating scabies, often in a single dose.<ref name="WHO"/><ref name=Clinic2009 /> It is the treatment of choice for crusted scabies, and is sometimes prescribed in combination with a topical agent.<ref name=Clinic2009 /><ref name=Ray2009 /> It has not been tested on infants, and is not recommended for children under six years of age.<ref name=Ray2009 />

[[Topical]] ivermectin preparations are effective for scabies in adults.<ref>{{cite journal | vauthors = Victoria J, Trujillo R | title = Topical ivermectin: a new successful treatment for scabies | journal = Pediatric Dermatology | volume = 18 | issue = 1 | pages = 63–65 | date = 2001 | pmid = 11207977 | doi = 10.1046/j.1525-1470.2001.018001063.x | s2cid = 39384922 }}</ref> It has also been useful for [[sarcoptic mange]], the veterinary analog of human scabies.<ref>{{cite journal | vauthors = Soll MD, d'Assonville JA, Smith CJ | title = Efficacy of topically applied ivermectin against sarcoptic mange (Sarcoptes scabiei var. bovis) of cattle | journal = Parasitology Research | volume = 78 | issue = 2 | pages = 120–122 | year = 1992 | pmid = 1557323 | doi = 10.1007/BF00931652 | s2cid = 28579947 }}</ref><ref>{{cite journal | vauthors = Carr PC, Brodell RT | title = IMAGES IN CLINICAL MEDICINE. Scabies | journal = The New England Journal of Medicine | volume = 374 | issue = 11 | pages = e13 | date = March 2016 | pmid = 26981951 | doi = 10.1056/NEJMicm1500116 }}</ref>

One review found that the efficacy of permethrin is similar to that of systemic or topical ivermectin.<ref>{{cite journal | vauthors = Rosumeck S, Nast A, Dressler C | title = Ivermectin and permethrin for treating scabies | journal = The Cochrane Database of Systematic Reviews | volume = 2018 | issue = 4 | pages = CD012994 | date = April 2018 | pmid = 29608022 | pmc = 6494415 | doi = 10.1002/14651858.CD012994 }}</ref> A separate review found that although oral ivermectin is usually effective for the treatment of scabies, it does have a higher treatment failure rate than topical permethrin.<ref>{{cite journal | vauthors = Dhana A, Yen H, Okhovat JP, Cho E, Keum N, Khumalo NP | title = Ivermectin versus permethrin in the treatment of scabies: A systematic review and meta-analysis of randomized controlled trials | journal = Journal of the American Academy of Dermatology | volume = 78 | issue = 1 | pages = 194–198 | date = January 2018 | pmid = 29241784 | doi = 10.1016/j.jaad.2017.09.006 | doi-access = free }}</ref> Another review found that oral ivermectin provided a reasonable balance between efficacy and safety.<ref name="Thadanipon2019">{{cite journal | vauthors = Thadanipon K, Anothaisintawee T, Rattanasiri S, Thakkinstian A, Attia J | title = Efficacy and safety of antiscabietic agents: A systematic review and network meta-analysis of randomized controlled trials | journal = Journal of the American Academy of Dermatology | volume = 80 | issue = 5 | pages = 1435–1444 | date = May 2019 | pmid = 30654070 | doi = 10.1016/j.jaad.2019.01.004 | doi-access = free }} {{open access}}</ref> A study has demonstrated that scabies is markedly reduced in populations taking ivermectin regularly;<ref>{{cite journal | vauthors = Crump A, Ōmura S | title = Ivermectin, 'wonder drug' from Japan: the human use perspective | journal = Proceedings of the Japan Academy. Series B, Physical and Biological Sciences | volume = 87 | issue = 2 | pages = 13–28 | date = 10 February 2011 | pmid = 21321478 | pmc = 3043740 | doi = 10.2183/pjab.87.13 | bibcode = 2011PJAB...87...13C }}</ref> the drug is widely used for treating scabies and other parasitic diseases, particularly among the poor and disadvantaged in the tropics, beginning with the developer Merck providing the drug at no cost to treat [[onchocerciasis]] from 1987.<ref>{{cite journal | vauthors = Laing R, Gillan V, Devaney E | title = Ivermectin - Old Drug, New Tricks? | journal = Trends in Parasitology | volume = 33 | issue = 6 | pages = 463–472 | date = June 2017 | pmid = 28285851 | pmc = 5446326 | doi = 10.1016/j.pt.2017.02.004 }} {{open access}}</ref>