Editing Paroxetine (section)

===Pharmacokinetics===
Paroxetine is well-absorbed following oral administration.<ref name="ReferenceA"/> It has an absolute [[bioavailability]] of about 50%, with evidence of a saturable [[first pass effect]].<ref name="ReferenceB">{{cite journal | vauthors = Kaye CM, Haddock RE, Langley PF, Mellows G, Tasker TC, Zussman BD, Greb WH | title = A review of the metabolism and pharmacokinetics of paroxetine in man | journal = Acta Psychiatrica Scandinavica. Supplementum | volume = 350 | pages = 60–75 | date = 1989 | pmid = 2530793 | doi = 10.1111/j.1600-0447.1989.tb07176.x | s2cid = 23769424 }}</ref> When taken orally, it achieves maximum concentration in about 6–10 hours<ref name="ReferenceA"/> and reaches steady-state in 7–14 days.<ref name="ReferenceB"/> Paroxetine exhibits significant interindividual variations in volume of distribution and clearance.<ref name="ReferenceB"/> Less than 2% of an oral dose is excreted in urine unchanged.<ref name="ReferenceB"/>

Paroxetine is a mechanism-based inhibitor of [[CYP2D6]].<ref name="Metabolism-guided drug design"/><ref name="ReferenceC">{{cite journal | vauthors = Jornil J, Jensen KG, Larsen F, Linnet K | title = Identification of cytochrome P450 isoforms involved in the metabolism of paroxetine and estimation of their importance for human paroxetine metabolism using a population-based simulator | journal = Drug Metabolism and Disposition | volume = 38 | issue = 3 | pages = 376–385 | date = March 2010 | pmid = 20007670 | doi = 10.1124/dmd.109.030551 | s2cid = 1795852 }}</ref>

[[File:Paroxetine metabolism.png|class=skin-invert-image|250px|thumb|right|Metabolism of paroxetine in humans<ref name="ReferenceC"/>]]