Editing Laxative (section)

===Laxative abuse===
Some of the less significant adverse effects of laxative abuse include [[dehydration]] (which causes tremors, weakness, fainting, blurred vision, kidney damage), [[hypotension|low blood pressure]], [[tachycardia|fast heart rate]], postural dizziness and [[syncope (medicine)|fainting]];<ref name="Laxative abuse review" /> however, laxative abuse can lead to potentially fatal [[acid-base imbalance|acid-base]], and [[electrolyte imbalance]]s.<ref name="Laxative abuse review" /> For example, severe [[hypokalaemia]] has been associated with [[distal renal tubular acidosis]] from laxative abuse.<ref name="Laxative abuse review" /> [[Metabolic alkalosis]] is the most common acid-base imbalance observed.<ref name="Laxative abuse review" /> Other significant adverse effects include [[rhabdomyolysis]],<ref name="Laxative abuse review" /> [[steatorrhoea]],<ref name="Laxative abuse review" /> [[inflammation]] and [[ulceration]] of colonic mucosa,<ref name="Laxative abuse review" /> [[pancreatitis]],<ref name="Laxative abuse review" /><ref name=Brown>{{cite journal |vauthors=Brown NW, Treasure JL, Campbell IC | title = Evidence for long-term pancreatic damage caused by laxative abuse in subjects recovered from anorexia nervosa | journal = International Journal of Eating Disorders | volume = 29 | issue = 2 | pages = 236–238 | year = 2001 | pmid = 11429987 | doi = 10.1002/1098-108X(200103)29:2<236::AID-EAT1014>3.0.CO;2-G }}</ref> [[kidney failure]],<ref name="Laxative abuse review" /><ref name=copeland>{{cite journal | author = Copeland PM | title = Renal failure associated with laxative abuse | journal = Psychother Psychosom | volume = 62 | issue = 3–4 | pages = 200–2 | year = 1994 | pmid = 7531354 | doi = 10.1159/000098619 | last5 = Alaminos | last4 = MacIas | last7 = Teijeiro | last6 = Alvarez | last3 = Ohye | last2 = Molina | last9 = Ortega | last8 = Muñoz | first8 = J. | first9 = I. | first2 = H. | first3 = Ch. | first4 = R. | first5 = A. | first6 = L. | first7 = J. }}</ref><ref name=wright>{{cite journal |vauthors=Wright LF, DuVal JW | title = Renal injury associated with laxative abuse | journal = South Med J | volume = 80 | issue = 10 | pages = 1304–6 | year = 1987 | pmid = 3660046 | doi = 10.1097/00007611-198710000-00024 }}</ref> [[factitious diarrhea]]<ref name="Laxative abuse review" /><ref>{{cite journal |vauthors=Oster JR, Materson BJ, Rogers AI | title = Laxative abuse syndrome | journal = Am. J. Gastroenterol. | volume = 74 | issue = 5 | pages = 451–8 | date = November 1980 | pmid = 7234824 }}</ref> and other problems.<ref name="Laxative abuse review">{{cite journal | vauthors = Roerig JL, Steffen KJ, Mitchell JE, Zunker C | title = Laxative abuse: epidemiology, diagnosis and management | journal = Drugs | volume = 70 | issue = 12 | pages = 1487–1503 | year = 2010 | pmid = 20687617 | doi = 10.2165/11898640-000000000-00000 | s2cid = 29007249 }}</ref> The colon will need more quantities of laxatives to keep functioning, this will result in a lazy colon, infections, irritable bowel syndrome, and potential liver damage.

Although some patients with eating disorders such as [[anorexia nervosa]] and [[bulimia nervosa]] abuse laxatives in an attempt to lose weight, laxatives act to speed up the transit of feces through the large intestine, which occurs after the absorption of nutrients in the small intestine is already complete. Thus, studies of laxative abuse have found that effects on body weight reflect primarily temporary losses of body water rather than energy (calorie) loss.<ref name="Laxative abuse review" /><ref name=Lacey>{{cite journal |vauthors=Lacey JH, Gibson E | title = Controlling weight by purgation and vomiting: A comparative study of bulimics | journal = Journal of Psychiatric Research | volume = 19 | issue = 2–3 | pages = 337–341 | year = 1985 | pmid = 3862833 | doi = 10.1016/0022-3956(85)90037-8 }}</ref><ref>{{Cite web|url=http://www.uptodate.com/contents/acid-base-and-electrolyte-abnormalities-with-diarrhea-or-ureteral-diversion|title=Acid-base and electrolyte abnormalities with diarrhea|website=www.uptodate.com|access-date=2017-12-12}}</ref>