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Hereditary haemochromatosis
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===Phlebotomy=== Early diagnosis is vital, as the late effects of iron accumulation can be wholly prevented by periodic [[Venipuncture|phlebotomies]] (by venesection) comparable in volume to [[blood donation]]s.<ref>{{cite web |url=http://www.mayoclinic.com/health/hemochromatosis/DS00455/DSECTION=7 |title=Hemochromatosis: Treatments and drugs |work=Mayo Foundation for Medical Education and Research (MFMER) |access-date=17 March 2007 |archive-date=7 March 2008 |archive-url=https://web.archive.org/web/20080307063713/http://www.mayoclinic.com/health/hemochromatosis/DS00455/DSECTION=7 |url-status=live }}</ref><ref>{{cite journal|title=EASL clinical practice guidelines for HFE hemochromatosis|doi=10.1016/j.jhep.2010.03.001|pmid=20471131|url=http://www.journal-of-hepatology.eu/article/S0168-8278%2810%2900197-2/abstract?cc=y=|volume=53|issue=1|journal=Journal of Hepatology|pages=3β22|year=2010|author1=European Association For The Study Of The Liver.|access-date=25 May 2015|archive-date=28 August 2021|archive-url=https://web.archive.org/web/20210828105049/https://www.journal-of-hepatology.eu/article/S0168-8278%2810%2900197-2/fulltext|url-status=live}}</ref> Phlebotomy (or [[bloodletting]]) is usually done at a weekly or each two weeks interval until ferritin levels are 50 ΞΌg/L or less. To prevent iron reaccumulation, subsequent phlebotomies are normally carried out about once every three to four months for males, and twice a year for females to keep the serum ferritin between 50 and 100 ug/L<ref>{{cite book|last1=Kowdley|first1=KV|last2=Bennett|first2=RL|last3=Motulsky|first3=AG|last4=Pagon|first4=RA|last5=Adam|first5=MP|last6=Ardinger|first6=HH|last7=Wallace|first7=SE|last8=Amemiya|first8=A|last9=Bean|first9=LJH|last10=Bird|first10=TD|last11=Dolan|first11=CR|last12=Fong|first12=CT|last13=Smith|first13=RJH|last14=Stephens|first14=K|title=''HFE''-Associated Hereditary Hemochromatosis|chapter=HFE Hemochromatosis|date=1993|publisher=University of Washington, Seattle|pmid=20301613|chapter-url=https://www.ncbi.nlm.nih.gov/books/NBK1440/|access-date=25 May 2015|archive-date=18 January 2017|archive-url=https://web.archive.org/web/20170118124842/https://www.ncbi.nlm.nih.gov/books/NBK1440/|url-status=live}}</ref>
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