Editing David Baltimore (section)

===== Splicing Control Research =====
Another concentration within Baltimore's lab in recent years was control of inflammatory and immune responses, specifically splicing control of gene expression after inflammatory stimuli.<ref name=":5" /> In 2013 they discovered that ordered expression of genes following an inflammatory stimulus was controlled by splicing, not transcription as previously supposed.<ref>{{cite journal | vauthors = Hao S, Baltimore D | title = RNA splicing regulates the temporal order of TNF-induced gene expression | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 110 | issue = 29 | pages = 11934–9 | date = July 2013 | pmid = 23812748 | doi = 10.1073/pnas.1309990110 | pmc = 3718113 | bibcode = 2013PNAS..11011934H | doi-access = free }}</ref> This led to further discoveries that delayed splicing was caused by introns, with the revelation that RNA-binding protein BUD13 acts at this intron to increase the amount of successful splicing (2 articles by Luke Frankiw published in 2019 and 2020).<ref>{{cite journal | vauthors = Frankiw L, Majumdar D, Burns C, Vlach L, Moradian A, Sweredoski MJ, Baltimore D | title = BUD13 Promotes a Type I Interferon Response by Countering Intron Retention in Irf7 | language = English | journal = Molecular Cell | volume = 73 | issue = 4 | pages = 803–814.e6 | date = February 2019 | pmid = 30639243 | doi = 10.1016/j.molcel.2018.11.038 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Frankiw L, Mann M, Li G, Joglekar A, Baltimore D | title = Alternative splicing coupled with transcript degradation modulates OAS1g antiviral activity | journal = RNA | volume = 26 | issue = 2 | pages = 126–136 | date = February 2020 | pmid = 31740586 | pmc = 6961538 | doi = 10.1261/rna.073825.119 }}</ref>

In an autobiographical piece published in Annual Review Immunology in 2019, Baltimore announced that half of his lab space at Caltech would be taken over by a new assistant professor in Fall 2018, and his current lab group would be the last. "I have been involved in research for 60 years, and I think it is time to leave the field to younger people."<ref name=":1" />