Editing Chloramphenicol (section)

===Drug interactions===
Administration of chloramphenicol concomitantly with bone marrow depressant drugs is contraindicated, although concerns over aplastic anaemia associated with ocular chloramphenicol have largely been discounted.<ref>{{cite web | title = Practice Guidance: OTC Chloramphenicol Eye Drops | url = http://www.rpsgb.org.uk/pdfs/otcchlorampheneyedropsguid.pdf | date = June 2005 | publisher = Royal Pharmaceutical Society of Great Britain (RPSGB) | archive-url = https://web.archive.org/web/20051022000549/http://www.rpsgb.org.uk/pdfs/otcchlorampheneyedropsguid.pdf | archive-date = 2005-10-22 }}</ref>

Chloramphenicol is a potent inhibitor of the [[cytochrome P450]] [[isoforms]] [[CYP2C19]] and [[CYP3A4]] in the liver.<ref>{{cite journal | vauthors = Park JY, Kim KA, Kim SL | title = Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes | journal = Antimicrobial Agents and Chemotherapy | volume = 47 | issue = 11 | pages = 3464–3469 | date = November 2003 | pmid = 14576103 | pmc = 253795 | doi = 10.1128/AAC.47.11.3464-3469.2003 }}</ref> Inhibition of CYP2C19 causes decreased metabolism and therefore increased levels of, for example, [[antidepressants]], [[antiepileptics]], [[proton-pump inhibitor]]s, and [[anticoagulant]]s if they are given concomitantly. Inhibition of CYP3A4 causes increased levels of, for example, [[calcium channel blocker]]s, [[immunosuppressants]], [[chemotherapeutic drugs]], [[benzodiazepine]]s, azole [[antifungals]], [[tricyclic antidepressant]]s, [[macrolide]] antibiotics, [[Selective serotonin reuptake inhibitor|SSRI]]s, [[statin]]s, [[Antiarrhythmic agent|cardiac antiarrhythmics]], [[Antiviral drug|antivirals]], [[anticoagulant]]s, and [[PDE5 inhibitor]]s.<ref name="Drug Insert from DailyMed" /><ref name=FASS>{{cite web | url = http://www.fass.se/LIF/produktfakta/fakta_lakare_artikel.jsp?articleID=18352 | trans-title = Facts for prescribers | title = Fakta för förskrivare | language = sv | publisher = FASS – Swedish National Drug Formulary | url-status = live | archive-url = https://web.archive.org/web/20020611044953/http://www.fass.se/LIF/produktfakta/fakta_lakare_artikel.jsp?articleID=18352 | archive-date = 2002-06-11 }}</ref>