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====Arthropods==== The most studied cartilage in arthropods is the branchial cartilage of ''[[Limulus polyphemus]]''. It is a vesicular cell-rich cartilage due to the large, spherical and vacuolated chondrocytes with no homologies in other arthropods. Other type of cartilage found in ''L. polyphemus'' is the endosternite cartilage, a fibrous-hyaline cartilage with chondrocytes of typical morphology in a fibrous component, much more fibrous than vertebrate hyaline cartilage, with [[mucopolysaccharide]]s immunoreactive against chondroitin sulfate antibodies. There are homologous tissues to the endosternite cartilage in other arthropods.<ref name="ColeHall2004">{{cite journal | vauthors = Cole AG, Hall BK | title = The nature and significance of invertebrate cartilages revisited: distribution and histology of cartilage and cartilage-like tissues within the Metazoa | journal = Zoology | volume = 107 | issue = 4 | pages = 261β73 | year = 2004 | pmid = 16351944 | doi = 10.1016/j.zool.2004.05.001 | bibcode = 2004Zool..107..261C }}</ref> The embryos of ''Limulus polyphemus'' express ColA and hyaluronan in the gill cartilage and the endosternite, which indicates that these tissues are fibrillar-collagen-based cartilage. The endosternite cartilage forms close to Hh-expressing ventral nerve cords and expresses ColA and SoxE, a Sox9 analog. This is also seen in gill cartilage tissue.<ref name="TarazonaEtAl2016">{{cite journal | vauthors = Tarazona OA, Slota LA, Lopez DH, Zhang G, Cohn MJ | title = The genetic program for cartilage development has deep homology within Bilateria | journal = Nature | volume = 533 | issue = 7601 | pages = 86β9 | date = May 2016 | pmid = 27111511 | doi = 10.1038/nature17398 | bibcode = 2016Natur.533...86T | s2cid = 3932905 }}</ref>
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