Editing Sjögren's disease (section)

=== Hormonal factors ===
[[Sex hormones]] seem to influence humoral and cell-mediated immune response, with [[estrogen]] being considered one of the biggest factors responsible for sex-[[immunologic]] [[Sexual dimorphism|dimorphism]].<ref name="pmid15485092">{{cite journal |vauthors=Cutolo M, Sulli A, Capellino S, Villaggio B, Montagna P, Seriolo B, Straub RH |title=Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity. |journal=Lupus |volume=13 |issue=9 |pages=635–8 |year=2004 |pmid=15485092 |doi=10.1191/0961203304lu1094oa|s2cid=23941507 }}</ref> [[Estrogen deficiency]] appears to play a role in the development of Sjögren's disease.<ref name=MavraganiFragoulis2012>{{cite journal|vauthors=Mavragani CP, Fragoulis GE, Moutsopoulos HM|title=Endocrine alterations in primary Sjögren's disease: an overview|journal=J Autoimmun|volume=39|issue=4|pages=354–8|date=Dec 2012|pmid=22695186|doi=10.1016/j.jaut.2012.05.011|type=Review}}</ref> It has been [[hypothesized]] that androgen administration to the ocular surface may serve as an effective therapy for dry eyes.<ref name="pmid10415627">{{cite journal |vauthors=Sullivan DA, Wickham LA, Rocha EM, Krenzer KL, Sullivan BD, Steagall R, Cermak JM, Dana MR, Ullman MD, Sato EH, Gao J, Rocha FJ, Ono M, Silveira LA, Lambert RW, Kelleher RS, Tolls DB, Toda I |title=Androgens and dry eye in Sjögren's syndrome |journal=Ann N Y Acad Sci |volume=876 |issue=1 |pages=312–24 |year=1999 |pmid=10415627 |doi=10.1111/j.1749-6632.1999.tb07656.x|bibcode=1999NYASA.876..312S |s2cid=33718591 }}</ref>