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===Evolution=== The fossil history of the Rubiaceae goes back at least as far as the [[Eocene]]. The geographic distribution of these fossils, coupled with the fact that they represent all three subfamilies, is indicative of an earlier origin for the family, probably in the [[Late Cretaceous]] or [[Paleocene]]. Although fossils dating back to the [[Cretaceous]] and [[Palaeocene]] have been referred to the family by various authors, none of these fossils has been confirmed as belonging to the Rubiaceae.<ref name="Graham2009"/> The oldest confirmed fossils, which are fruits that strongly resemble those of the genus ''[[Emmenopterys]]'', were found in the [[Washington (state)|Washington]] and are 48β49 million years old. A fossil infructescence and fruit found in 44 million-year-old strata in [[Oregon]] was assigned to ''Emmenopterys dilcheri'', an extinct species. The next-oldest fossils date to the [[Late Eocene]] and include ''[[Canthium]]'' from [[Australia]], ''[[Faramea]]'' from Panama, ''[[Guettarda]]'' from [[New Caledonia]], and ''Paleorubiaceophyllum'', an extinct genus from the southeastern [[United States]].<ref name ="Graham2009"/> Fossil Rubiaceae are known from three regions in the Eocene (North America north of Mexico, Mexico-Central America-Caribbean, and Southeast Pacific-Asia). In the [[Oligocene]], they are found in these three regions plus Africa. In the [[Miocene]], they are found in these four regions plus South America and Europe.<ref name ="Graham2009"/>
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