Editing Progesterone (section)

===Nervous system===
Progesterone, like [[pregnenolone]] and [[dehydroepiandrosterone]] (DHEA), belongs to an important group of endogenous steroids called [[neurosteroid]]s. It can be metabolized within all parts of the [[central nervous system]].<ref name="pmid558037">{{cite journal | vauthors = Hanukoglu I, Karavolas HJ, Goy RW | title = Progesterone metabolism in the pineal, brain stem, thalamus and corpus callosum of the female rat | journal = Brain Research | volume = 125 | issue = 2 | pages = 313–324 | date = April 1977 | pmid = 558037 | doi = 10.1016/0006-8993(77)90624-2 | s2cid = 35814845 | url = https://zenodo.org/record/890908 | access-date = 28 June 2019 | archive-date = 5 March 2021 | archive-url = https://web.archive.org/web/20210305233844/https://zenodo.org/record/890908 | url-status = live }}</ref>

Neurosteroids are [[neuromodulator]]s, and are [[neuroprotective]], [[neurogenic]], and regulate [[neurotransmission]] and [[myelin]]ation.<ref name="pmid15135772">{{cite journal | vauthors = Schumacher M, Guennoun R, Robert F, Carelli C, Gago N, Ghoumari A, Gonzalez Deniselle MC, Gonzalez SL, Ibanez C, Labombarda F, Coirini H, Baulieu EE, De Nicola AF | display-authors = 6 | title = Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination | journal = Growth Hormone & IGF Research | volume = 14 | issue = Suppl A | pages = S18–S33 | date = June 2004 | pmid = 15135772 | doi = 10.1016/j.ghir.2004.03.007 }}</ref> The effects of progesterone as a neurosteroid are mediated predominantly through its interactions with non-nuclear PRs, namely the mPRs and [[PGRMC1]], as well as certain other receptors, such as the σ<sub>1</sub> and nACh receptors.<ref name="pmid24065876">{{cite journal | vauthors = Singh M, Su C, Ng S | title = Non-genomic mechanisms of progesterone action in the brain | journal = Frontiers in Neuroscience | volume = 7 | pages = 159 | date = September 2013 | pmid = 24065876 | pmc = 3776940 | doi = 10.3389/fnins.2013.00159 | doi-access = free }}</ref>