Editing Paroxetine (section)

===Pharmacodynamics===
Paroxetine is the most potent and one of the most specific selective [[serotonin]] (5-hydroxytryptamine, 5-HT) reuptake inhibitors (SSRIs).<ref>{{cite journal | vauthors = Mellerup ET, Plenge P | title = High affinity binding of 3H-paroxetine and 3H-imipramine to rat neuronal membranes | journal = Psychopharmacology | volume = 89 | issue = 4 | pages = 436–439 | date = July 1986 | pmid = 2944152 | doi = 10.1007/BF02412117 | s2cid = 6037759 }}</ref> It also binds to the [[Allosteric regulation|allosteric]] site of the serotonin transporter, similarly to [[escitalopram]], though less potently so.<ref>{{cite journal | vauthors = Mansari ME, Wiborg O, Mnie-Filali O, Benturquia N, Sánchez C, Haddjeri N | title = Allosteric modulation of the effect of escitalopram, paroxetine and fluoxetine: in-vitro and in-vivo studies | journal = The International Journal of Neuropsychopharmacology | volume = 10 | issue = 1 | pages = 31–40 | date = February 2007 | pmid = 16448580 | doi = 10.1017/S1461145705006462 | doi-access = free }}</ref> Paroxetine also inhibits the reuptake of [[norepinephrine]] to a lesser extent (<50&nbsp;nmol/L).<ref>{{cite journal | vauthors = Owens JM, Knight DL, Nemeroff CB | title = [Second generation SSRIS: human monoamine transporter binding profile of escitalopram and R-fluoxetine] | journal = L'Encephale | volume = 28 | issue = 4 | pages = 350–355 | date = 1 August 2002 | pmid = 12232544 }}</ref> Based on evidence from four weeks of administration in rats, the equivalent of 20&nbsp;mg paroxetine taken once daily occupies approximately 88% of serotonin transporters in the [[prefrontal cortex]].<ref name="ReferenceA"/>  Paroxetine is a phenylpiperidine and might have some affinity for opioid receptors.<ref>{{cite journal | doi=10.1523/ENEURO.0063-22.2022 | title=Paroxetine Increases δ Opioid Responsiveness in Sensory Neurons | date=2022 | journal=eNeuro | volume=9 | issue=4 | pmid=35882549 | pmc=9347309 | vauthors = Brackley AD, Jeske NA | quote="Paroxetine is a phenylpiperidine and nearly all phenylpiperidines used clinically in research capacities are opioids. Interestingly, this structure is part of the morphine and fentanyl molecules. Furthermore, paroxetine-induced analgesia is dose dependently reversed by opioid receptor antagonists"}}</ref><ref>{{cite journal |title=Possible Involvement of Opioidergic and Serotonergic Mechanisms in Antinociceptive Effect of Paroxetine in Acute Pain |date=2004 |url=https://www.sciencedirect.com/science/article/pii/S1347861319325216 |journal=Journal of Pharmacological Sciences |doi=10.1254/jphs.94.161 |pmid=14978354 |access-date=8 January 2025 |volume=94 |issue=2 |pages=161–165 | vauthors = Duman EN, Kesim M, Kadioglu M, Yaris E, Kalyoncu NI, Erciyes N }}</ref>

{| class="wikitable" style="width:200px;"
|+Binding profile<ref name = GG>{{cite book|vauthors=Brunton L, Chabner B, Knollman B |title=Goodman and Gilman's The Pharmacological Basis of Therapeutics |year=2010 |publisher=McGraw-Hill Professional |isbn=978-0-07-162442-8 |edition=12th |location=New York}}</ref><ref name="ReferenceA"/><ref name="pmid11543737">{{cite journal | vauthors = Owens MJ, Knight DL, Nemeroff CB | title = Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine | journal = Biological Psychiatry | volume = 50 | issue = 5 | pages = 345–350 | date = September 2001 | pmid = 11543737 | doi = 10.1016/s0006-3223(01)01145-3 | s2cid = 11247427 }}</ref><ref name=PDSP>{{cite web|title=PDSP K<sub>i</sub> Database |website=Psychoactive Drug Screening Program (PDSP)|author1-link=Bryan Roth |vauthors=Roth BL, Driscol J |url=http://pdsp.med.unc.edu/pdsp.php |publisher=University of North Carolina at Chapel Hill and the United States National Institute of Mental Health |access-date=22 November 2013 |date=12 January 2011 |archive-url=https://web.archive.org/web/20131108013656/http://pdsp.med.unc.edu/pdsp.php |archive-date=8 November 2013}}</ref> Paroxetine
|-
! Receptor !! K<sub>i</sub> (nM)
|-
| [[Serotonin transporter|SERT]] || 0.07 – 0.2
|-
| [[Norepinephrine transporter|NET]] || 40 – 85
|-
| [[Dopamine transporter|DAT]] || 490
|-
| [[Dopamine receptor D2|D<sub>2</sub>]] || 7,700
|-
| [[5-HT1A receptor|5-HT<sub>1A</sub>]] || 21,200
|-
| [[5-HT2A receptor|5-HT<sub>2A</sub>]] || 6,300
|-
| [[5-HT2C receptor|5-HT<sub>2C</sub>]] || 9,000
|-
| [[Alpha-1 adrenergic receptor|α<sub>1</sub>]] || 1,000 – 2,700
|-
| [[Alpha-2 adrenergic receptor|α<sub>2</sub>]] || 3,900
|-
| [[Muscarinic acetylcholine receptor M1|M<sub>1</sub>]] || 72
|-
| [[Histamine H1 receptor|H<sub>1</sub>]] || 13,700 – 23,700
|}