Editing Oxycodone (section)

====Distribution====
Oxycodone has a [[volume of distribution]] of 2.6L/kg,<ref name="Drugbank">{{cite web |title=Oxycodone |url=https://www.drugbank.ca/drugs/DB00497 |website=www.drugbank.ca |access-date=24 January 2019 |archive-date=25 January 2019 |archive-url=https://web.archive.org/web/20190125074846/https://www.drugbank.ca/drugs/DB00497 |url-status=live }}</ref> in the blood it is distributed to [[skeletal muscle]], liver, intestinal tract, lungs, [[spleen]], and brain.<ref name="OxyContinInsertUS" /> At equilibrium the unbound concentration in the brain is threefold higher than the unbound concentration in blood.<ref>{{cite journal | vauthors = Boström E, Simonsson US, Hammarlund-Udenaes M | title = In vivo blood-brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics | journal = Drug Metabolism and Disposition | volume = 34 | issue = 9 | pages = 1624–1631 | date = September 2006 | pmid = 16763013 | doi = 10.1124/dmd.106.009746 | s2cid = 772550 }}</ref> Conventional oral preparations start to reduce pain within 10 to 15 minutes on an empty stomach; in contrast, OxyContin starts to reduce pain within one hour.<ref name=AHFS2018/>