Editing Ménière's disease (section)

=== Poorly supported ===
* As of 2014, [[betahistine]] is often used as it is inexpensive and safe;<ref name=Har2014/> but evidence does not justify its use in Ménière's disease.<ref name="PMID11279734">{{Cite journal|last1=James|first1=A. L.|last2=Burton|first2=M. J.|date=2001|title=Betahistine for Menière's disease or syndrome|journal=The Cochrane Database of Systematic Reviews |volume=2020 |issue= 1|pages=CD001873|doi=10.1002/14651858.CD001873|issn=1469-493X|pmid=11279734|pmc=6769057}}</ref><ref name="PMID26797774">{{Cite journal| pmc= 4721211 |year= 2016 |last1= Adrion |first1=C|title=Efficacy and safety of betahistine treatment in patients with Meniere's disease: Primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial (BEMED trial)|journal=BMJ|volume=352|pages=h6816|last2=Fischer|first2=C. S.| last3= Wagner |first3= J |last4= Gürkov |first4= R |last5= Mansmann |first5= U|last6=Strupp| first6=M |display-authors= 3| doi=10.1136/bmj.h6816|pmid=26797774}}</ref> However, recent [[pharmacokinetic]] experiments have shown that combination therapy with [[Monoamine oxidase inhibitor|Monoamine oxidase inhibitors]] can drastically increase the bioavailability of betahistine in humans,<ref name="DOI10.3389/fneur.2023.1271640">Michael Strupp, Grant C. Churchill, Ivonne Naumann, Ulrich Mansmann, Amani Al Tawil, Anastasia Golentsova, Nicolina Goldschagg: ''Examination of betahistine bioavailability in combination with the monoamine oxidase B inhibitor, selegiline, in humans—a non-randomized, single-sequence, two-period titration, open label single-center phase 1 study (PK-BeST).'' In: ''Frontiers in Neurology.'' 2023, Band 14 {{doi|10.3389/fneur.2023.1271640}}.</ref> and improve cochlear blood flow in [[guinea pigs]].<ref name="DOI10.1177/00034894221098803">Benedikt Kloos, Mattis Bertlich, Jennifer L. Spiegel, Saskia Freytag, Susanne K. Lauer, Martin Canis, Bernhard G. Weiss, Friedrich Ihler: ''Low Dose Betahistine in Combination With Selegiline Increases Cochlear Blood Flow in Guinea Pigs.'' In: ''Annals of Otology Rhinology & Laryngology.'' 2022, Band 132, Nummer 5, S.&nbsp;519–526 {{doi|10.1177/00034894221098803}}.</ref>
* Transtympanic micropressure pulses were investigated in two systematic reviews. Neither found evidence to justify this technique.<ref name="PMID25756795">{{cite journal | pmid = 25756795 | doi=10.1002/14651858.CD008419.pub2 | issue=3 | title=Positive pressure therapy for Ménière's disease or syndrome | year=2015 | journal=Cochrane Database Syst Rev | page=CD008419 | author=van Sonsbeek S, Pullens B, van Benthem PP| volume=2015 | pmc=11026870 }}</ref><ref name="PMID25346252">{{Cite journal|last2=Rutka|first2=J. A. |last3= Hendry |first3= J |last4= Browning |first4= G. G.|display-authors= 3| year=2015|title=Positive pressure therapy for Meniere's syndrome/disease with a Meniett device: A systematic review of randomised controlled trials|journal=Clinical Otolaryngology|volume=40|issue=3|pages=197–207|doi=10.1111/coa.12344|pmid=25346252|last1=Syed|first1=M. I.|s2cid=1025535 }}</ref>
* Intratympanic [[steroid]]s were investigated in three systematic reviews. The data were found to be insufficient to decide if this therapy has positive effects.<ref name="PMID19923807">{{Cite journal|last2=Parnes|first2=L. S.|year=2009|title=Intratympanic steroids for inner ear disorders: A review|journal=Audiology and Neurotology |volume= 14 |issue= 6|pages=373–382|doi=10.1159/000241894|pmid=19923807|last1=Hu|first1=A|s2cid=38726308}}</ref><ref name="pmid25215266">{{cite journal|year=2014|title=Intratympanic Therapies for Menière's disease|journal=Current Otorhinolaryngology Reports|volume=2|issue=3|pages=137–143|doi=10.1007/s40136-014-0055-8|pmc=4157672|pmid=25215266|vauthors=Miller MW, Agrawal Y}}</ref><ref>{{Cite journal|last1=Phillips|first1=John S.|last2=Westerberg|first2=Brian|date=2011-07-06|title=Intratympanic steroids for Ménière's disease or syndrome |journal= The Cochrane Database of Systematic Reviews|issue=7|pages=CD008514|doi=10.1002/14651858.CD008514.pub2|issn=1469-493X|pmid=21735432}}</ref>
* Evidence does not support the use of alternative medicine such as [[acupuncture]] or herbal supplements.<ref name=NIH2016/>