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==Clinical research== According to the [[American Cancer Society]] as of 2013, "there is no reliable scientific evidence at this time that lipoic acid prevents the development or spread of cancer".<ref>{{cite web|url=http://www.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/pharmacologicalandbiologicaltreatment/lipoic-acid|title=Lipoic Acid|date=November 2008|publisher=[[American Cancer Society]]|access-date=5 October 2013|archive-date=24 April 2015|archive-url=https://web.archive.org/web/20150424110743/http://www.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/pharmacologicalandbiologicaltreatment/lipoic-acid|url-status=dead}}</ref> As of 2015, intravenously administered ALA is unapproved anywhere in the world except Germany for [[diabetic neuropathy]], but has been proven reasonably safe and effective.<ref>{{Cite journal |last1=Prado |first1=Mario B. |last2=Adiao |first2=Karen Joy B. |date=2024-01-29 |title=Ranking Alpha Lipoic Acid and Gamma Linolenic Acid in Terms of Efficacy and Safety in the Management of Adults With Diabetic Peripheral Neuropathy: A Systematic Review and Network Meta-analysis |url=https://pubmed.ncbi.nlm.nih.gov/38295879 |journal=Canadian Journal of Diabetes |volume=48 |issue=4 |pages=S1499β2671(24)00023β6 |doi=10.1016/j.jcjd.2024.01.007 |issn=2352-3840 |pmid=38295879}}</ref> As of 2012, there was no good evidence alpha lipoic acid helps people with [[mitochondrial disorders]].<ref name="pmid22513923">{{cite journal | vauthors = Pfeffer G, Majamaa K, Turnbull DM, Thorburn D, Chinnery PF | title = Treatment for mitochondrial disorders | journal = Cochrane Database Syst Rev | issue = 4 | pages = CD004426 | date = April 2012 | volume = 2012 | pmid = 22513923 | doi = 10.1002/14651858.CD004426.pub3 | pmc = 7201312 }}</ref> A 2018 review recommended ALA as an anti-obesity supplement with low dosage (< 600 mg/day) for a short period (<10 weeks).<ref name="Namazi">{{cite journal | last1=Namazi | first1=Nazli | last2=Larijani | first2=Bagher | last3=Azadbakht | first3=Leila | title=Alpha-lipoic acid supplement in obesity treatment: A systematic review and meta-analysis of clinical trials | journal=Clinical Nutrition| volume=37 | issue=2 | year=2018 | issn=0261-5614 | doi=10.1016/j.clnu.2017.06.002 | pages=419β428|pmid=28629898}}</ref>
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