Editing Estrogen (section)

====Masculinization in rodents====
In rodents, estrogens (which are locally aromatized from androgens in the brain) play an important role in psychosexual differentiation, for example, by masculinizing territorial behavior;<ref name="pmid19804754">{{cite journal | vauthors = Wu MV, Manoli DS, Fraser EJ, Coats JK, Tollkuhn J, Honda S, Harada N, Shah NM | title = Estrogen masculinizes neural pathways and sex-specific behaviors | journal = Cell | volume = 139 | issue = 1 | pages = 61–72 | date = October 2009 | pmid = 19804754 | pmc = 2851224 | doi = 10.1016/j.cell.2009.07.036 }}</ref> the same is not true in humans.<ref name="pmid19707181">{{cite journal | vauthors = Rochira V, Carani C | title = Aromatase deficiency in men: a clinical perspective | journal = Nature Reviews. Endocrinology | volume = 5 | issue = 10 | pages = 559–568 | date = October 2009 | pmid = 19707181 | doi = 10.1038/nrendo.2009.176 | s2cid = 22116130 | url = https://zenodo.org/record/890683 }}</ref> In humans, the masculinizing effects of prenatal androgens on behavior (and other tissues, with the possible exception of effects on bone) appear to act exclusively through the androgen receptor.<ref name="pmid11534997">{{cite journal | vauthors = Wilson JD | title = Androgens, androgen receptors, and male gender role behavior | journal = Hormones and Behavior | volume = 40 | issue = 2 | pages = 358–366 | date = September 2001 | pmid = 11534997 | doi = 10.1006/hbeh.2001.1684 | url = http://pdfs.semanticscholar.org/75bb/071beb950f66cd032b9d5a9633c255f80660.pdf | url-status = dead | s2cid = 20480423 | archive-url = https://web.archive.org/web/20190226183821/http://pdfs.semanticscholar.org/75bb/071beb950f66cd032b9d5a9633c255f80660.pdf | archive-date = 26 February 2019 }}</ref> Consequently, the utility of rodent models for studying human psychosexual differentiation has been questioned.<ref name="pmid16876166">{{cite journal | vauthors = Baum MJ | title = Mammalian animal models of psychosexual differentiation: when is 'translation' to the human situation possible? | journal = Hormones and Behavior | volume = 50 | issue = 4 | pages = 579–588 | date = November 2006 | pmid = 16876166 | doi = 10.1016/j.yhbeh.2006.06.003 | s2cid = 7465192 }}</ref>