Editing Chloramphenicol (section)

===Dose monitoring===
[[Blood plasma|Plasma]] levels of chloramphenicol must be monitored in neonates and patients with abnormal liver function. Plasma levels should be monitored in all children under the age of four, the elderly, and patients with [[kidney failure]].
Because efficacy and toxicity of chloramphenicol are associated with a maximum serum concentration, peak levels (one hour after the intravenous dose is given) should be 10–20&nbsp;μg/mL with toxicity {{nowrap|> 40 μg/mL}}; trough levels (taken immediately before a dose) should be 5–10&nbsp;μg/mL.<ref name="Laboratory guidelines for monitoring of antimicrobial drugs">{{cite journal | vauthors = Hammett-Stabler CA, Johns T | title = Laboratory guidelines for monitoring of antimicrobial drugs. National Academy of Clinical Biochemistry | journal = Clinical Chemistry | volume = 44 | issue = 5 | pages = 1129–1140 | date = May 1998 | pmid = 9590397 | doi = 10.1093/clinchem/44.5.1129 | doi-access = free }}<!--|access-date=17 April 2014--></ref><ref name="Lexicomp Online Database">{{cite web|title=Chloramphenicol (Lexi-Drugs)|url=http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/6582|work=Lexi-Comp Online|access-date=18 April 2014|url-status=live|archive-url=https://web.archive.org/web/20130726053121/http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/6582|archive-date=26 July 2013}}</ref>