Editing Angiogenesis (section)

==== Class 3 semaphorins ====
[[Semaphorin#Classes|Class 3 semaphorin]]s (SEMA3s) regulate angiogenesis by modulating [[endothelial cells|endothelial cell]] adhesion, migration, proliferation, survival and the recruitment of [[pericyte]]s.<ref name="Mecollari_2014" /> Furthermore, [[semaphorin]]s can interfere with VEGF-mediated angiogenesis since both SEMA3s and [[VEGF-A]] compete for [[neuropilin]] receptor binding at endothelial cells.<ref name="Soker_1998">{{cite journal | vauthors = Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M | title = Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor | journal = Cell | volume = 92 | issue = 6 | pages = 735–745 | date = March 1998 | pmid = 9529250 | doi = 10.1016/s0092-8674(00)81402-6 | s2cid = 547080 | doi-access = free }}</ref><ref name="Herzog_2011">{{cite journal | vauthors = Herzog B, Pellet-Many C, Britton G, Hartzoulakis B, Zachary IC | title = VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation | journal = Molecular Biology of the Cell | volume = 22 | issue = 15 | pages = 2766–2776 | date = August 2011 | pmid = 21653826 | pmc = 3145551 | doi = 10.1091/mbc.E09-12-1061 }}</ref> The relative expression levels of SEMA3s and VEGF-A may therefore be important for angiogenesis.<ref name="Mecollari_2014" />