Editing Adrenal gland (section)

==Gene and protein expression==
{{Further |Bioinformatics#Gene and protein expression}}
The&nbsp;[[human genome]]&nbsp;includes approximately 20,000 protein coding genes and 70% of these&nbsp;[[Gene expression|genes are expressed]]&nbsp;in the normal adult adrenal glands.<ref>{{Cite web|url=https://www.proteinatlas.org/humanproteome/adrenal+gland|title=The human proteome in adrenal gland – The Human Protein Atlas|website=www.proteinatlas.org|access-date=2017-09-21}}</ref><ref>{{Cite journal|last1=Uhlén|first1=Mathias|last2=Fagerberg|first2=Linn|last3=Hallström|first3=Björn M.|last4=Lindskog|first4=Cecilia|last5=Oksvold|first5=Per|last6=Mardinoglu|first6=Adil|last7=Sivertsson|first7=Åsa|last8=Kampf|first8=Caroline|last9=Sjöstedt|first9=Evelina|date=2015-01-23|title=Tissue-based map of the human proteome|journal=Science|language=en|volume=347|issue=6220|pages=1260419|doi=10.1126/science.1260419|issn=0036-8075|pmid=25613900|s2cid=802377}}</ref>&nbsp;Only some 250 genes are more specifically expressed in the adrenal glands compared to other organs and tissues.&nbsp;The adrenal-gland-specific genes with the highest level of expression include members of the [[cytochrome P450]] superfamily of enzymes. Corresponding proteins are expressed in the different compartments of the adrenal gland, such as [[CYP11A1]], [[HSD3B2]] and [[FDX1]] involved in [[steroid hormone]] synthesis and expressed in cortical cell layers, and [[Phenylethanolamine N-methyltransferase|PNMT]] and [[Dopamine beta-hydroxylase|DBH]] involved in [[Norepinephrine|noradrenaline]] and [[Epinephrine|adrenaline]] synthesis and expressed in the medulla.<ref>{{Cite journal|last1=Bergman|first1=Julia|last2=Botling|first2=Johan|last3=Fagerberg|first3=Linn|last4=Hallström|first4=Björn M.|last5=Djureinovic|first5=Dijana|last6=Uhlén|first6=Mathias|last7=Pontén|first7=Fredrik|date=2017-02-01|title=The Human Adrenal Gland Proteome Defined by Transcriptomics and Antibody-Based Profiling|journal=Endocrinology|volume=158|issue=2|pages=239–251|doi=10.1210/en.2016-1758|pmid=27901589|issn=0013-7227|doi-access=free}}</ref>