Editing Adenosine (section)

=== Viruses ===
{{See also|Nucleoside analogue}}
The adenosine analog [[NITD008]] has been reported to directly inhibit the recombinant RNA-dependent [[RNA polymerase]] of the [[dengue virus]] by terminating its RNA chain synthesis. This interaction suppresses peak [[viremia]] and rise in [[cytokine]]s and prevents lethality in infected animals, raising the possibility of a new treatment for this [[flavivirus]].<ref>{{Cite journal | vauthors = Yin Z, Chen YL, Schul W, Wang QY, Gu F, Duraiswamy J, Kondreddi RR, Niyomrattanakit P, Lakshminarayana SB, Goh A, Xu HY, Liu W, Liu B, Lim JY, Ng CY, Qing M, Lim CC, Yip A, Wang G, Chan WL, Tan HP, Lin K, Zhang B, Zou G, Bernard KA, Garrett C, Beltz K, Dong M, Weaver M, He H, Pichota A, Dartois V, Keller TH, Shi PY | title = An adenosine nucleoside inhibitor of dengue virus | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 48 | pages = 20435–20439 | date = December 2009 | pmid = 19918064 | pmc = 2787148 | doi = 10.1073/pnas.0907010106 | doi-access = free | bibcode = 2009PNAS..10620435Y }}</ref> The 7-deaza-adenosine analog has been shown to inhibit the replication of the [[hepatitis C virus]].<ref>{{Cite journal | vauthors = Olsen DB, Eldrup AB, Bartholomew L, Bhat B, Bosserman MR, Ceccacci A, Colwell LF, Fay JF, Flores OA, Getty KL, Grobler JA, LaFemina RL, Markel EJ, Migliaccio G, Prhavc M, Stahlhut MW, Tomassini JE, MacCoss M, Hazuda DJ, Carroll SS | title = A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties | journal = Antimicrobial Agents and Chemotherapy | volume = 48 | issue = 10 | pages = 3944–3953 | date = October 2004 | pmid = 15388457 | pmc = 521892 | doi = 10.1128/AAC.48.10.3944-3953.2004 }}</ref> [[BCX4430]] is protective against [[Ebola virus disease|Ebola]] and [[Marburg virus disease|Marburg]] viruses.<ref>{{Cite journal | vauthors = Warren TK, Wells J, Panchal RG, Stuthman KS, Garza NL, Van Tongeren SA, Dong L, Retterer CJ, Eaton BP, Pegoraro G, Honnold S, Bantia S, Kotian P, Chen X, Taubenheim BR, Welch LS, Minning DM, Babu YS, Sheridan WP, Bavari S | title = Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 | journal = Nature | volume = 508 | issue = 7496 | pages = 402–405 | date = April 2014 | pmid = 24590073 | pmc = 7095208 | doi = 10.1038/nature13027 | bibcode = 2014Natur.508..402W }}</ref> Such adenosine analogs are potentially clinically useful since they can be taken orally.