Editing Vitamin B6 (section)

===In plants===
Plant synthesis of vitamin B<sub>6</sub> contributes to protection from sunlight. [[Ultraviolet#Subtypes|Ultraviolet-B radiation]] (UV-B) from sunlight stimulates plant growth, but in high amounts can increase production of tissue-damaging [[reactive oxygen species]] (ROS), i.e., [[oxidants]]. Using ''[[Arabidopsis thaliana]]'' (common name: thale cress), researchers demonstrated that UV-B exposure increased pyridoxine biosynthesis, but in a mutant variety, pyridoxine biosynthesis capacity was not [[Enzyme induction and inhibition|inducible]], and as a consequence, ROS levels, [[lipid peroxidation]], and cell proteins associated with tissue damage were all elevated.<ref name="Havaux2009">{{cite journal |vauthors=Havaux M, Ksas B, Szewczyk A, Rumeau D, Franck F, Caffarri S, Triantaphylidès C |title=Vitamin B6 deficient plants display increased sensitivity to high light and photo-oxidative stress |journal=BMC Plant Biol |volume=9 |issue= 1|pages=130 |date=November 2009 |pmid=19903353 |pmc=2777905 |doi=10.1186/1471-2229-9-130 |url= |doi-access=free |bibcode=2009BMCPB...9..130H }}</ref><ref>{{cite journal |vauthors=Ristilä M, Strid H, Eriksson LA, Strid A, Sävenstrand H |title=The role of the pyridoxine (vitamin B6) biosynthesis enzyme PDX1 in ultraviolet-B radiation responses in plants |journal=Plant Physiol Biochem |volume=49 |issue=3 |pages=284–92 |date=March 2011 |pmid=21288732 |doi=10.1016/j.plaphy.2011.01.003 |url=https://oru.diva-portal.org/smash/get/diva2:137027/FULLTEXT01 |access-date=March 20, 2024 |archive-date=January 6, 2024 |archive-url=https://web.archive.org/web/20240106034824/http://oru.diva-portal.org/smash/get/diva2:137027/FULLTEXT01 |url-status=live }}</ref><ref>{{cite journal |vauthors=Czégény G, Kőrösi L, Strid A, Hideg E |title=Multiple roles for Vitamin B<sub>6</sub> in plant acclimation to UV-B |journal=Scientific Reports |volume=9 |issue= 1|pages=1259 |date=February 2019 |pmid= 30718682|doi=10.1038/s41598-018-38053-w |url=|pmc=6361899 |bibcode=2019NatSR...9.1259C }}</ref> Biosynthesis of [[chlorophyll]] depends on aminolevulinic acid synthase, a PLP-dependent enzyme that uses [[succinyl-CoA]] and [[glycine]] to generate [[aminolevulinic acid]], a chlorophyll precursor.<ref name="Parra2018"/> In addition, plant mutants with severely limited capacity to synthesize vitamin B<sub>6</sub> have stunted root growth, because synthesis of [[plant hormone]]s such as [[auxin]] require the vitamin as an enzyme cofactor.<ref name="Parra2018"/>