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===Medications=== There is no significant association between [[antidepressant]] medication exposure and miscarriage.<ref name="Ross LE 436–443">{{cite journal | vauthors = Ross LE, Grigoriadis S, Mamisashvili L, Vonderporten EH, Roerecke M, Rehm J, Dennis CL, Koren G, Steiner M, Mousmanis P, Cheung A | title = Selected pregnancy and delivery outcomes after exposure to antidepressant medication: a systematic review and meta-analysis | journal = JAMA Psychiatry | volume = 70 | issue = 4 | pages = 436–43 | date = April 2013 | pmid = 23446732 | doi = 10.1001/jamapsychiatry.2013.684 | doi-access = | s2cid = 2065578 }}</ref> The risk of miscarriage is not likely decreased by discontinuing [[Selective serotonin reuptake inhibitor|SSRIs]] before pregnancy.<ref name="auto3">{{cite journal | vauthors = Dalke KB, Wenzel A, Kim DR | title = Depression and Anxiety During Pregnancy: Evaluating the Literature in Support of Clinical Risk-Benefit Decision-Making | journal = Current Psychiatry Reports | volume = 18 | issue = 6 | pages = 59 | date = June 2016 | pmid = 27091646 | doi = 10.1007/s11920-016-0698-x | s2cid = 984767 }}</ref> Some available data suggest that there is a small increased risk of miscarriage for women taking any [[antidepressant]],<ref name="auto4">{{cite journal | vauthors = Broy P, Bérard A | title = Gestational exposure to antidepressants and the risk of spontaneous abortion: a review | journal = Current Drug Delivery | volume = 7 | issue = 1 | pages = 76–92 | date = January 2010 | pmid = 19863482 | doi = 10.2174/156720110790396508 }}</ref><ref name="auto5">{{cite journal | vauthors = Nakhai-Pour HR, Broy P, Bérard A | title = Use of antidepressants during pregnancy and the risk of spontaneous abortion | journal = CMAJ | volume = 182 | issue = 10 | pages = 1031–7 | date = July 2010 | pmid = 20513781 | pmc = 2900326 | doi = 10.1503/cmaj.091208 }}</ref> though this risk becomes less [[statistically significant]] when excluding studies of poor quality.<ref name="Ross LE 436–443"/><ref name="auto6">{{cite journal | vauthors = Yonkers KA, Blackwell KA, Glover J, Forray A | title = Antidepressant use in pregnant and postpartum women | journal = Annual Review of Clinical Psychology | volume = 10 | issue = 1 | pages = 369–92 | date = 2014-01-01 | pmid = 24313569 | pmc = 4138492 | doi = 10.1146/annurev-clinpsy-032813-153626 }}</ref> Medicines that increase the risk of miscarriage include: * [[retinoids]] * [[nonsteroidal anti-inflammatory drugs]] (NSAIDs), such as [[ibuprofen]] * [[misoprostol]] * [[methotrexate]]<ref name="NHS-Miscarriage-Causes"/> * [[statin]]s<ref>{{cite journal | vauthors = Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC, Sperling L, Virani SS, Yeboah J | title = 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines | journal = Journal of the American College of Cardiology | volume = 73 | issue = 24 | pages = 3168–3209 | date = June 2019 | pmid = 30423391 | doi = 10.1016/j.jacc.2018.11.002 | doi-access = free }}</ref>
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