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==Uses== R/S-LA and RLA are widely available as over-the-counter nutritional supplements in the United States in the form of capsules, tablets, and aqueous liquids, and have been marketed as [[antioxidants]] and pertaining to cellular glucose utilization for metabolic disorders and type 2 diabetes.<ref name=lpi/> Although the body can synthesize LA, it can also be absorbed from the diet. Dietary supplementation in doses from 200β600 mg is likely to provide up to 1000 times the amount available from a regular diet. Gastrointestinal absorption is variable and decreases with the use of food. It is therefore recommended that dietary LA be taken 30β60 minutes before or at least 120 minutes after a meal. Maximum blood levels of LA are achieved 30β60 minutes after dietary supplementation, and it is thought to be largely metabolized in the liver.<ref>{{cite journal |last1=McIlduff |first1=Courtney E |last2=Rutkove |first2=Seward B |date=2011-01-01 |title=Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy |journal=Therapeutics and Clinical Risk Management |volume=7 |pages=377β385 |doi=10.2147/TCRM.S11325 |issn=1176-6336 |pmc=3176171 |pmid=21941444 |doi-access=free }}</ref> In Germany, LA is approved as a drug for the treatment of [[diabetic neuropathy]] since 1966 and is available as a non-prescription pharmaceutical.<ref name="Ziegle">{{cite journal |last1=Ziegle |first1=D. |last2=Reljanovic |first2=M |last3=Mehnert |first3=H |last4=Gries |first4=F. A. |title=Ξ±-Lipoic acid in the treatment of diabetic polyneuropathy in Germany |journal=Experimental and Clinical Endocrinology & Diabetes |volume=107 |issue=7 |pages=421β30 |year=1999 |pmid=10595592 |doi=10.1055/s-0029-1212132}}</ref>
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