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=== Natural infertility === Before [[puberty]], humans are naturally infertile; their [[gonad]]s have not yet developed the [[gametes]] required to reproduce: boys' [[testicle]]s have not developed the [[sperm cell]]s required to impregnate a female; girls have not begun the process of [[ovulation]] which activates the fertility of their egg cells (ovulation is confirmed by the first [[menstrual cycle]], known as [[menarche]], which signals the biological possibility of pregnancy). Infertility in [[child]]ren is commonly referred to as ''[[prepubescence]]'' (or being ''prepubescent'', an adjective used to also refer to humans without [[secondary sex characteristic]]s){{citation needed|date=April 2023}}. The absence of fertility in children is considered a natural part of [[Development of the human body|human growth]] and [[child development]], as the [[hypothalamus]] in their brain is still underdeveloped and cannot release the [[hormone]]s required to activate the gonads' gametes. Fertility in children before the ages of eight or nine is considered a disease known as ''[[precocious puberty]]''. This disease is usually triggered by a [[brain tumor]] or [[brain injury|other related injury]].<ref>{{cite web|url=http://kidshealth.org/parent/medical/sexual/precocious.html|title=Precocious Puberty|publisher=KidsHealth|access-date=2021-08-31|archive-date=23 January 2016|archive-url=https://web.archive.org/web/20160123083430/http://kidshealth.org/parent/medical/sexual/precocious.html|url-status=live}}</ref>
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