Editing Human skin color (section)

===== SLC45A2 =====
[[SLC45A2|Solute carrier family 45 member 2]] (SLC45A2 or MATP) aids in the transport and processing of tyrosine, a precursor to melanin. It has also been shown to be one of the significant components of the skin color of modern Europeans through its ''Phe374Leu'' ([[rs16891982]]<ref>{{Cite web |title=rs16891982 RefSNP Report - dbSNP - NCBI |url=https://www.ncbi.nlm.nih.gov/snp/rs16891982 |access-date=2022-10-02 |website=www.ncbi.nlm.nih.gov}}</ref>) allele that has been directly correlated with skin color variation across a range of populations.<ref>{{cite journal |last1=Adhikari |first1=Kaustubh |title=A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia |journal=Nature Communications |volume=10 |issue=1 |pages=358 |date=21 January 2019 |doi=10.1038/s41467-018-08147-0 |pmid=30664655 |pmc=6341102 |bibcode=2019NatCo..10..358A }}</ref><ref>{{cite journal |last1=Deng |first1=Lian |title=Adaptation of human skin color in various populations |journal=Hereditas |volume=155 |pages=1 |date=15 June 2017 |doi=10.1186/s41065-017-0036-2 |pmid=28701907 |pmc=5502412 |doi-access=free }}</ref><ref name=Lopez/><ref name=Valenzuela /><ref name=Stokowski2007 /> This variation is ubiquitous in European populations but extremely rare elsewhere and shows strong signs of selection.<ref name=Soejima2006 /><ref name=Khai2012 /><ref>{{cite journal |title=Evidence for Recent Positive Selection at the Human AIM1 Locus in a European Population |journal=Molecular Biology and Evolution |date=January 2006 |volume=23 |issue=1 |pages=179–188 |doi=10.1093/molbev/msj018 |pmid=16162863 |last1=Soejima |first1=M |last2=Tachida |first2=H |last3=Ishida |first3=T |last4=Sano |first4=A |last5=Koda |first5=Y }}</ref>