Editing Hippocampus (section)

===Role in social memory===
{{Further|Collective memory}}
The hippocampus has received renewed attention for its role in [[social memory]]. Epileptic human subjects with depth electrodes in the left posterior, left anterior or right anterior hippocampus demonstrate distinct, individual cell responses when presented with faces of presumably recognizable famous people.<ref name="Quiroga et al.">{{cite journal | vauthors = Quiroga RQ, Reddy L, Kreiman G, Koch C, Fried I | title = Invariant visual representation by single neurons in the human brain | journal = Nature | volume = 435 | issue = 7045 | pages = 1102–1107 | date = June 2005 | pmid = 15973409 | doi = 10.1038/nature03687 | bibcode = 2005Natur.435.1102Q | s2cid = 1234637 | url = https://resolver.caltech.edu/CaltechAUTHORS:20130816-103222719 }}</ref> Associations among facial and vocal identity were similarly mapped to the hippocampus of rheseus monkeys. Single neurons in the CA1 and CA3 responded strongly to social stimulus recognition by MRI. The CA2 was not distinguished, and may likely comprise a proportion of the claimed CA1 cells in the study.<ref name="Sliwa et al.">{{cite journal | vauthors = Sliwa J, Planté A, Duhamel JR, Wirth S | title = Independent Neuronal Representation of Facial and Vocal Identity in the Monkey Hippocampus and Inferotemporal Cortex | journal = Cerebral Cortex | volume = 26 | issue = 3 | pages = 950–966 | date = March 2016 | pmid = 25405945 | doi = 10.1093/cercor/bhu257 }}</ref> The dorsal CA2 and ventral CA1 subregions of the hippocampus have been implicated in social memory processing. Genetic inactivation of CA2 pyramidal neurons leads to pronounced loss of social memory, while maintaining intact sociability in mice.<ref name="Hitti and Siegelbaum">{{cite journal | vauthors = Hitti FL, Siegelbaum SA | title = The hippocampal CA2 region is essential for social memory | journal = Nature | volume = 508 | issue = 7494 | pages = 88–92 | date = April 2014 | pmid = 24572357 | pmc = 4000264 | doi = 10.1038/nature13028 | bibcode = 2014Natur.508...88H }}</ref> Similarly, ventral CA1 pyramidal neurons have also been demonstrated as critical for social memory under optogenetic control in mice.<ref name="Okuyama et al.">{{cite journal | vauthors = Okuyama T, Kitamura T, Roy DS, Itohara S, Tonegawa S | title = Ventral CA1 neurons store social memory | journal = Science | volume = 353 | issue = 6307 | pages = 1536–1541 | date = September 2016 | pmid = 27708103 | pmc = 5493325 | doi = 10.1126/science.aaf7003 | bibcode = 2016Sci...353.1536O }}</ref><ref name="Meira et al.">{{cite journal | vauthors = Meira T, Leroy F, Buss EW, Oliva A, Park J, Siegelbaum SA | title = A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics | journal = Nature Communications | volume = 9 | issue = 1 | pages = 4163 | date = October 2018 | pmid = 30301899 | pmc = 6178349 | doi = 10.1038/s41467-018-06501-w | bibcode = 2018NatCo...9.4163M }}</ref>