Editing Hemolysis (section)

===Extravascular hemolysis===

'''Extravascular hemolysis''' refers to hemolysis taking place in the [[liver]], [[spleen]], [[bone marrow]], and [[lymph nodes]].<ref name="Stanley 2018" /> In this case little hemoglobin escapes into [[blood plasma]].<ref name="Muller Jacobsen Healy McMickan 2006 pp. 229–241" /> The [[macrophages]] of the [[reticuloendothelial system]] in these organs [[phagocytosis|engulf and destroy]] structurally-defective red blood cells, or those with antibodies attached, and release unconjugated bilirubin into the blood plasma circulation.<ref name="Rhodes Varacallo 2019">{{cite journal | last1=Rhodes | first1=Carl E. | last2=Varacallo | first2=Matthew | title=Physiology, Oxygen Transport | website=NCBI Bookshelf | date=2019-03-04 | pmid=30855920 | url=https://www.ncbi.nlm.nih.gov/books/NBK538336/ | access-date=2019-05-04}}</ref><ref name=Sokol81>{{cite journal |vauthors=Sokol RJ, Hewitt S, Stamps BK |title=Autoimmune haemolysis: an 18-year study of 865 cases referred to a regional transfusion centre |journal=Br Med J (Clin Res Ed) |volume=282 |issue=6281 |pages=2023–7 |date=June 1981 |pmid=6788179 |pmc=1505955 |doi=10.1136/bmj.282.6281.2023 }}</ref> Typically, the spleen destroys mildly abnormal red blood cells or those coated with [[Immunoglobulin G|IgG-type antibodies]],<ref name="BRAUNSTEIN.EVAN 2019">{{cite web | author=Braunstein, Evan | title=Overview of Hemolytic Anemia – Hematology and Oncology | website=Merck Manuals Professional Edition | date=2019-05-03 | url=https://www.merckmanuals.com/professional/hematology-and-oncology/anemias-caused-by-hemolysis/overview-of-hemolytic-anemia?query=Autoimmune%20Hemolytic%20Anemia | language=la | access-date=2019-05-05}}</ref><ref name="Hypersplenism 2019">{{cite web | title=Hypersplenism: MedlinePlus Medical Encyclopedia | website=MedlinePlus | date=2019-04-30 | url=https://medlineplus.gov/ency/article/001314.htm | access-date=2019-05-08}}</ref> while severely abnormal red blood cells or those coated with [[Immunoglobulin M|IgM-type antibodies]] are destroyed in the circulation or in the liver.<ref name="BRAUNSTEIN.EVAN 2019" />

If extravascular hemolysis is extensive, [[hemosiderin]] can be deposited in the spleen, bone marrow, kidney, liver, and other organs, resulting in [[hemosiderosis]].<ref name="Muller Jacobsen Healy McMickan 2006 pp. 229–241"/>