Editing Fever (section)

=== Hyperpyrexia ===
Hyperpyrexia is an extreme elevation of [[body temperature]] which, depending upon the source, is classified as a [[core body temperature]] greater than or equal to {{convert|40|or|41|C|F|0}}; the range of hyperpyrexia includes cases considered severe (≥ 40&nbsp;°C) and extreme (≥ 42&nbsp;°C).<ref name="Harrisons20th" /><ref name="MDMA-Hyperpyrexia systematic review">{{cite journal | vauthors = Grunau BE, Wiens MO, Brubacher JR | title = Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review | journal = Canadian Journal of Emergency Medicine | volume = 12 | issue = 5 | pages = 435–442 | date = September 2010 | pmid = 20880437 | doi = 10.1017/s1481803500012598 | quote = Dantrolene may also be associated with improved survival and reduced complications, especially in patients with extreme (≥ 42&nbsp;°C) or severe (≥ 40&nbsp;°C) hyperpyrexia | doi-access = free }}</ref><ref name="Neurobiology of hyperthermia">{{cite book | editor=Sharma HS | title=Neurobiology of Hyperthermia | date=2007 | publisher=Elsevier | isbn=978-0080549996 | pages=175–177, 485 | edition=1st | url=https://books.google.com/books?id=Vk1UTlmEwrQC&pg=485 | access-date=19 November 2016 | quote=Despite the myriad of complications associated with heat illness, an elevation of core temperature above 41.0&nbsp;°C (often referred to as fever or hyperpyrexia) is the most widely recognized symptom of this syndrome. | url-status=live | archive-url=https://web.archive.org/web/20170908174330/https://books.google.com/books?id=Vk1UTlmEwrQC&pg=485#v=onepage&q=hyperpyrexia%20core%20temperature&f=false | archive-date=8 September 2017  }}</ref> It differs from [[hyperthermia]] in that one's [[Human thermoregulation#Control system|thermoregulatory system's set point]] for body temperature is set above normal, then heat is generated to achieve it. In contrast, hyperthermia involves body temperature rising above its set point due to outside factors.<ref name="Harrisons20th" /><ref>See section in Chapter 15 therein, the section on "Fever versus hyperthermia".</ref> The high temperatures of hyperpyrexia are considered [[medical emergency|medical emergencies]], as they may indicate a serious underlying condition or lead to severe morbidity (including permanent [[brain damage]]), or to death.<ref name="EM01" /> A common cause of hyperpyrexia is an [[intracranial hemorrhage]].<ref name="Harrisons20th" /> Other causes in emergency room settings include Malignant Catatonia, [[sepsis]], [[Kawasaki syndrome]],<ref name="Marx 2006 2506">Marx (2006), p. 2506.</ref> [[neuroleptic malignant syndrome]], [[drug overdose]], [[serotonin syndrome]], and [[thyroid storm]].<ref name="EM01">{{cite journal | vauthors = McGugan EA | title = Hyperpyrexia in the emergency department | journal = Emergency Medicine | volume = 13 | issue = 1 | pages = 116–120 | date = March 2001 | pmid = 11476402 | doi = 10.1046/j.1442-2026.2001.00189.x }}</ref>