Editing Endomembrane system (section)

== Evolution ==
The origin of the endomembrane system is linked to the origin of eukaryotes themselves and the origin of eukaryoties to the endosymbiotic origin of [[Mitochondrion|mitochondria]]. Many models have been put forward to explain the origin of the endomembrane system (reviewed in<ref name="Martin2015">{{cite journal | vauthors = Martin WF, Garg S, Zimorski V | title = Endosymbiotic theories for eukaryote origin | journal = Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences | volume = 370 | issue = 1678 | pages = 20140330 | date = September 2015 | pmid = 26323761 | pmc = 4571569 | doi = 10.1098/rstb.2014.0330 }}</ref>). The most recent concept suggests that the endomembrane system evolved from outer membrane vesicles the endosymbiotic mitochondrion secreted, and got enclosed within infoldings of the host prokaryote (in turn, a result of the ingestion of the endosymbiont).<ref name="Gould2016">{{cite journal | vauthors = Gould SB, Garg SG, Martin WF | title = Bacterial Vesicle Secretion and the Evolutionary Origin of the Eukaryotic Endomembrane System | journal = Trends in Microbiology | volume = 24 | issue = 7 | pages = 525–534 | date = July 2016 | pmid = 27040918 | doi = 10.1016/j.tim.2016.03.005 | url = http://www.cell.com/trends/microbiology/fulltext/S0966-842X(16)00074-3 }}</ref> This OMV (outer membrane vesicles)-based model for the origin of the endomembrane system is currently the one that requires the fewest novel inventions at eukaryote origin and explains the many connections of mitochondria with other compartments of the cell.<ref name="MurleyNunnari2016">{{cite journal | vauthors = Murley A, Nunnari J | title = The Emerging Network of Mitochondria-Organelle Contacts | journal = Molecular Cell | volume = 61 | issue = 5 | pages = 648–653 | date = March 2016 | pmid = 26942669 | pmc = 5554544 | doi = 10.1016/j.molcel.2016.01.031 }}</ref> Currently, this "inside-out" hypothesis (which states that the [[alphaproteobacteria]], the ancestral mitochondria, were engulfed by the [[Bleb (cell biology)|blebs]] of an [[Asgard (archaea)| asgardarchaeon]], and later the blebs fused leaving infoldings which would eventually become the endomembrane system) is favored more than the outside-in one (which suggested that the endomembrane system arose due to infoldings within the archaeal membrane).