Editing Dopamine (section)

====Immune system====

In the immune system dopamine acts upon receptors present on immune cells, especially [[lymphocyte]]s.<ref name="Buttarelli">{{cite journal | vauthors = Buttarelli FR, Fanciulli A, Pellicano C, Pontieri FE | title = The dopaminergic system in peripheral blood lymphocytes: from physiology to pharmacology and potential applications to neuropsychiatric disorders | journal = Current Neuropharmacology | volume = 9 | issue = 2 | pages = 278–88 | date = June 2011 | pmid = 22131937 | pmc = 3131719 | doi = 10.2174/157015911795596612 }}</ref> Dopamine can also affect immune cells in the [[spleen]], [[bone marrow]], and [[circulatory system]].<ref name="pmid19896530"/> In addition, dopamine can be synthesized and released by immune cells themselves.<ref name=Buttarelli/> The main effect of dopamine on lymphocytes is to reduce their activation level. The functional significance of this system is unclear, but it affords a possible route for interactions between the nervous system and immune system, and may be relevant to some autoimmune disorders.<ref name="pmid19896530">{{cite journal | vauthors = Sarkar C, Basu B, Chakroborty D, Dasgupta PS, Basu S | title = The immunoregulatory role of dopamine: an update | journal = Brain, Behavior, and Immunity | volume = 24 | issue = 4 | pages = 525–28 | date = May 2010 | pmid = 19896530 | pmc = 2856781 | doi = 10.1016/j.bbi.2009.10.015 }}</ref>