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=== Branched DNA === {{further|Branched DNA|DNA nanotechnology}} <div class="thumb tright" style="background:#f9f9f9; border:1px solid #ccc; margin:0.5em;"> {| border="0" cellpadding="2" cellspacing="0" style="width:200px; font-size:85%; border:1px solid #ccc; margin:0.3em;" |[[File:Branch-dna-single.svg|95px]] |[[File:Branch-DNA-multiple.svg|95px]] |- |align=center|Single branch |align=center|Multiple branches |} <div style="border: none; width:200px;font-size: 90%;"><div class="thumbcaption">[[Branched DNA]] can form networks containing multiple branches.</div></div></div> In DNA, [[DNA end#Frayed ends|fraying]] occurs when non-complementary regions exist at the end of an otherwise complementary double-strand of DNA. However, branched DNA can occur if a third strand of DNA is introduced and contains adjoining regions able to hybridize with the frayed regions of the pre-existing double-strand. Although the simplest example of branched DNA involves only three strands of DNA, complexes involving additional strands and multiple branches are also possible.<ref>{{cite journal | vauthors = Seeman NC | title = DNA enables nanoscale control of the structure of matter | journal = Quarterly Reviews of Biophysics | volume = 38 | issue = 4 | pages = 363β71 | date = November 2005 | pmid = 16515737 | pmc = 3478329 | doi = 10.1017/S0033583505004087 }}</ref> Branched DNA can be used in [[nanotechnology]] to construct geometric shapes, see the section on [[#Uses in technology|uses in technology]] below.
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