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Coronary artery disease
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===Risk assessment=== There are various risk assessment systems for determining the risk of coronary artery disease, with various emphasis on the different variables above. A notable example is [[Framingham Score]], used in the [[Framingham Heart Study]]. It is mainly based on age, gender, diabetes, total cholesterol, HDL cholesterol, tobacco smoking, and systolic blood pressure. When predicting risk in younger adults (18β39 years old), the Framingham Risk Score remains below 10β12% for all deciles of baseline-predicted risk.<ref>{{cite journal | vauthors = Berry JD, Lloyd-Jones DM, Garside DB, Greenland P | title = Framingham risk score and prediction of coronary heart disease death in young men | journal = American Heart Journal | volume = 154 | issue = 1 | pages = 80β86 | date = July 2007 | pmid = 17584558 | pmc = 2279177 | doi = 10.1016/j.ahj.2007.03.042 }}</ref> [[Polygenic score]] is another way of risk assessment. In one study the relative risk of incident coronary events was 91% higher among participants at high genetic risk than among those at low genetic risk.<ref>{{cite journal | vauthors = Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S | display-authors = 6 | title = Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease | journal = The New England Journal of Medicine | volume = 375 | issue = 24 | pages = 2349β58 | date = December 2016 | pmid = 27959714 | pmc = 5338864 | doi = 10.1056/NEJMoa1605086 }}</ref>
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