Editing Common cold (section)

===Zinc===
{{Main|Zinc and the common cold}}

[[Zinc supplements]] may shorten the duration of colds by up to 33% and reduce the severity of symptoms if supplementation begins within 24&nbsp;hours of the onset of symptoms.<ref name=NIH2016Zinc/><ref name=Cochrane2013/><ref name="Zinc CC 2018 SystRev">{{cite journal |vauthors=Rondanelli M, Miccono A, Lamburghini S, Avanzato I, Riva A, Allegrini P, Faliva MA, Peroni G, Nichetti M, Perna S |display-authors=6 |title=Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and ''Echinacea'' in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds |journal=Evidence-Based Complementary and Alternative Medicine |volume=2018 |pages=5813095 |year=2018 |pmid=29853961 |pmc=5949172 |doi=10.1155/2018/5813095 |quote=Considering zinc, the supplementation may shorten the duration of colds by approximately 33%. CC patients may be instructed to try zinc within 24 hours of onset of symptoms. |doi-access=free}}</ref><ref name=Hemila_2017a>{{cite journal |vauthors=Hemilä H, Fitzgerald JT, Petrus EJ, Prasad A |title=Zinc Acetate Lozenges May Improve the Recovery Rate of Common Cold Patients: An Individual Patient Data Meta-Analysis |journal=Open Forum Infectious Diseases |volume=4 |issue=2 |pages=ofx059 |year=2017 |pmid=28480298 |pmc=5410113 |doi=10.1093/ofid/ofx059 |quote=The 3-fold increase in the rate of recovery from the common cold is a clinically important effect. The optimal formulation of zinc lozenges and an ideal frequency of their administration should be examined. Given the evidence of efficacy, common cold patients may be instructed to try zinc acetate lozenges within 24 hours of onset of symptoms.}}</ref><ref name=Hemila_2016>{{cite journal |vauthors=Hemilä H, Petrus EJ, Fitzgerald JT, Prasad A |title=Zinc acetate lozenges for treating the common cold: an individual patient data meta-analysis |journal=British Journal of Clinical Pharmacology |volume=82 |issue=5 |pages=1393–1398 |date=November 2016 |pmid=27378206 |pmc=5061795 |doi=10.1111/bcp.13057}}</ref> Some zinc remedies directly applied to the inside of the nose have led to the [[anosmia|loss of the sense of smell]].<ref name=NIH2016Zinc/><ref>{{cite web |url=https://www.fda.gov/Drugs/DrugSafety/DrugSafetyPodcasts/ucm167282.htm |title=Loss of Sense of Smell with Intranasal Cold Remedies Containing Zinc |website=[[Food and Drug Administration]] |year=2009 |archive-url=https://web.archive.org/web/20150604024153/https://www.fda.gov/Drugs/DrugSafety/DrugSafetyPodcasts/ucm167282.htm |archive-date=4 June 2015}}</ref> A 2017 review did not recommend the use of zinc for the common cold for various reasons;<ref name=Mal2017/> whereas a 2017 and 2018 review both recommended the use of zinc, but also advocated further research on the topic.<ref name="Zinc CC 2018 SystRev" /><ref name="Hemila_2017a" />