Editing Antiandrogen (section)

====Transgender hormone therapy====
{{See also|Feminizing hormone therapy#Antiandrogens}}

Antiandrogens are used to prevent or reverse [[masculinization]] and to facilitate [[feminization (biology)|feminization]] in [[transgender women]] and some [[non-binary gender|non-binary]] transfeminine individuals who are undergoing [[feminizing hormone therapy|hormone therapy]] and who have not undergone [[sex reassignment surgery]] or [[orchiectomy]].<ref name="pmid21714669">{{cite journal | vauthors = Bockting W, Coleman E, De Cuypere G | title = Care of transsexual persons | journal = N. Engl. J. Med. | volume = 364 | issue = 26 | pages = 2559–60; author reply 2560 | year = 2011 | pmid = 21714669 | doi = 10.1056/NEJMc1104884 }}</ref> Besides estrogens, the main antiandrogens that have been used for this purpose are cyproterone acetate, spironolactone, and GnRH modulators.<ref name="pmid21714669" /> Nonsteroidal antiandrogens like bicalutamide are also used for this indication.<ref name="pmid30256230">{{cite journal | vauthors = Randolph JF | title = Gender-Affirming Hormone Therapy for Transgender Females | journal = Clin Obstet Gynecol | volume = 61 | issue = 4 | pages = 705–721 | date = December 2018 | pmid = 30256230 | doi = 10.1097/GRF.0000000000000396 | s2cid = 52821192 }}</ref><ref name="pmid21714669" /> In addition to use in transgender women, antiandrogens, mainly GnRH modulators, are used as [[puberty blocker]]s to prevent the onset of [[puberty]] in [[transgender youth|transgender girl]]s until they are older and ready to begin hormone therapy.<ref name="pmid25404716">{{cite journal | vauthors = Vance SR, Ehrensaft D, Rosenthal SM | title = Psychological and medical care of gender nonconforming youth | journal = Pediatrics | volume = 134 | issue = 6 | pages = 1184–92 | year = 2014 | pmid = 25404716 | doi = 10.1542/peds.2014-0772 | s2cid = 5743822 | url = http://pediatrics.aappublications.org/content/pediatrics/134/6/1184.full.pdf | access-date = 2018-05-14 | archive-date = 2018-05-15 | archive-url = https://web.archive.org/web/20180515045718/http://pediatrics.aappublications.org/content/pediatrics/134/6/1184.full.pdf | url-status = live }}</ref>