Editing Α-Ketoglutaric acid (section)

=====β-Ketoglutaric acid and TET-2=====
β-Ketoglutaric acid has been detected in the saliva of individuals chewing [[betel quid chewing|betel quid]], a complex mixture derived from [[betel nut]]s mixed with various other materials. Chronic chewing betel quid is associated with the development of certain cancers, particularly those in the [[oral cavity]]. The study showed that β-ketoglutaric acid bound to the cancer-promoting protein [[TET-2]] thereby inhibiting α-ketoglutarate's binding to this protein. Since α-ketoglutarate's binding of TET-2 is thought to be required for it to activate TET-2, the study suggested that β-ketoglutaric acid may not fulfill the requirements for TET-2 to be activatable and therefore may prove able to block α-ketoglutarate's cancer-promoting as well as inflammation-promoting and other actions that involve its activation of TET-2.<ref name="pmid37830116">{{cite journal | vauthors = Bhatkar D, Ananda N, Lokhande KB, Khunteta K, Jain P, Hebale A, Sarode SC, Sharma NK | title = Organic Acids Derived from Saliva-amalgamated Betel Quid Filtrate Are Predicted as a Ten-eleven Translocation-2 Inhibitor | journal = Journal of Cancer Prevention | volume = 28 | issue = 3 | pages = 115–130 | date = September 2023 | pmid = 37830116 | pmc = 10564634 | doi = 10.15430/JCP.2023.28.3.115 | url = }}</ref>