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===Genetic testing=== Mutation analysis of the ''ATP7B'' gene, as well as other genes linked to copper accumulation in the liver, may be performed. Once a mutation is confirmed, family members can be screened for the disease as part of [[clinical genetics]] family counseling.<ref name=Ala/> Regional distributions of genes associated with Wilson's disease are important to follow, as this can help clinicians design appropriate screening strategies. Since mutations of the ''ATP7B'' gene vary between populations, research and genetic testing done in countries such as the USA or United Kingdom can pose problems, as they tend to have more mixed populations.<ref>{{Cite journal|title = Regional distribution of mutations of the ATP7B gene in patients with Wilson disease: impact on genetic testing|journal = Human Genetics|date = 2006-06-22|issn = 0340-6717|pages = 151β159|volume = 120|issue = 2|doi = 10.1007/s00439-006-0202-5|language = en|first = Peter|last = Ferenci|pmid=16791614|s2cid = 10124665}}</ref>
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