Editing Statin (section)

===Diabetes===
The relationship between statin use and risk of developing [[diabetes mellitus|diabetes]] remains unclear and the results of reviews are mixed.<ref name="pmid20167359">{{cite journal | vauthors = Sattar N, Preiss D, Murray HM, Welsh P, Buckley BM, de Craen AJ, Seshasai SR, McMurray JJ, Freeman DJ, Jukema JW, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RG, Shepherd J, Davis BR, Pressel SL, Marchioli R, Marfisi RM, Maggioni AP, Tavazzi L, Tognoni G, Kjekshus J, Pedersen TR, Cook TJ, Gotto AM, Clearfield MB, Downs JR, Nakamura H, Ohashi Y, Mizuno K, Ray KK, Ford I | title = Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials | journal = Lancet | volume = 375 | issue = 9716 | pages = 735–742 | date = February 2010 | pmid = 20167359 | doi = 10.1016/S0140-6736(09)61965-6 | s2cid = 11544414 }}</ref><ref name="Chou2016">{{cite journal | vauthors = Chou R, Dana T, Blazina I, Daeges M, Jeanne TL | title = Statins for Prevention of Cardiovascular Disease in Adults: Evidence Report and Systematic Review for the US Preventive Services Task Force | journal = JAMA | volume = 316 | issue = 19 | pages = 2008–2024 | date = November 2016 | pmid = 27838722 | doi = 10.1001/jama.2015.15629 | type = Review | doi-access = free | title-link = doi }}</ref><ref name="Rochlani2017">{{cite journal | vauthors = Rochlani Y, Kattoor AJ, Pothineni NV, Palagiri RD, Romeo F, Mehta JL | title = Balancing Primary Prevention and Statin-Induced Diabetes Mellitus Prevention | journal = The American Journal of Cardiology | volume = 120 | issue = 7 | pages = 1122–1128 | date = October 2017 | pmid = 28797470 | doi = 10.1016/j.amjcard.2017.06.054 | type = Review | bibcode = 1981AmJC...48..728H }}</ref><ref>{{cite journal | vauthors = He Y, Li X, Gasevic D, Brunt E, McLachlan F, Millenson M, Timofeeva M, Ioannidis JP, Campbell H, Theodoratou E | title = Statins and Multiple Noncardiovascular Outcomes: Umbrella Review of Meta-analyses of Observational Studies and Randomized Controlled Trials | journal = Annals of Internal Medicine | volume = 169 | issue = 8 | pages = 543–553 | date = October 2018 | pmid = 30304368 | doi = 10.7326/M18-0808 | s2cid = 52953760 }}</ref> Higher doses have a greater effect, but the decrease in cardiovascular disease outweighs the risk of developing diabetes.<ref name="pmid21693744">{{cite journal | vauthors = Preiss D, Seshasai SR, Welsh P, Murphy SA, Ho JE, Waters DD, DeMicco DA, Barter P, Cannon CP, Sabatine MS, Braunwald E, Kastelein JJ, de Lemos JA, Blazing MA, Pedersen TR, Tikkanen MJ, Sattar N, Ray KK | title = Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis | journal = JAMA | volume = 305 | issue = 24 | pages = 2556–2564 | date = June 2011 | pmid = 21693744 | doi = 10.1001/jama.2011.860 | doi-access = free | title-link = doi | hdl = 10044/1/39305 | hdl-access = free }}</ref> Use in postmenopausal women is associated with an increased risk for diabetes.<ref name="Culver 2012">{{cite journal | vauthors = Culver AL, Ockene IS, Balasubramanian R, Olendzki BC, Sepavich DM, Wactawski-Wende J, Manson JE, Qiao Y, Liu S, Merriam PA, Rahilly-Tierny C, Thomas F, Berger JS, Ockene JK, Curb JD, Ma Y | title = Statin use and risk of diabetes mellitus in postmenopausal women in the Women's Health Initiative | journal = Archives of Internal Medicine | volume = 172 | issue = 2 | pages = 144–152 | date = January 2012 | pmid = 22231607 | doi = 10.1001/archinternmed.2011.625 | doi-access = free | title-link = doi }}</ref> The exact mechanism responsible for the possible increased risk of diabetes mellitus associated with statin use is unclear.<ref name="Rochlani2017"/> However, recent findings have indicated the inhibition of [[HMG-CoA reductase|HMGCoAR]] as a key mechanism.<ref>{{cite journal | vauthors = Carmena R, Betteridge DJ | title = Diabetogenic Action of Statins: Mechanisms | journal = Current Atherosclerosis Reports | volume = 21 | issue = 6 | pages = 23 | date = April 2019 | pmid = 31037345 | doi = 10.1007/s11883-019-0780-z | s2cid = 140506916 }}</ref> Statins are thought to decrease cells' uptake of glucose from the bloodstream in response to the [[hormone]] [[insulin]].<ref name="Rochlani2017"/> One way this is thought to occur is by interfering with cholesterol synthesis which is necessary for the production of certain proteins responsible for glucose uptake into cells such as [[GLUT1]].<ref name="Rochlani2017"/>