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=== Hypertrophic cardiomyopathy === The breed does have instances of the genetic disorder [[hypertrophic cardiomyopathy]] (HCM). Other domestic cat breeds prone to HCM include [[Persian cat|Persian]],<ref>{{Cite web |url=https://www.vet.cornell.edu/departments-centers-and-institutes/cornell-feline-health-center/health-information/feline-health-topics/hypertrophic-cardiomyopathy/ |title=Hypertrophic Cardiomyopathy |publisher=Cornell University College of Veterinary Medicine|date=January 2014 |access-date=11 January 2020}}</ref> [[Ragdoll]], [[Norwegian Forest cat]], [[Siberian cat]]s, [[British Shorthair]] and [[Maine Coon]];<ref name=":8">{{Cite journal|last1=Kittleson|first1=Mark D.|last2=Meurs|first2=Kathryn M.|last3=Harris|first3=Samantha P.|date=December 2015|title=The Genetic Basis of Hypertrophic Cardiomyopathy in Cats and Humans|journal=Journal of Veterinary Cardiology |volume=17|issue=Suppl 1|pages=S53βS73|doi=10.1016/j.jvc.2015.03.001|issn=1760-2734|pmc=5909964|pmid=26776594}}</ref> however, any domestic cat including mixed breeds can acquire HCM.<ref name=":9">{{Cite web|url=https://www.medvetforpets.com/feline-hypertrophic-cardiomyopathy-hcm/|title=Feline Hypertrophic Cardiomyopathy (HCM)|date=2 December 2016|publisher=MedVet Medical & Cancer Centers for Pets|access-date=31 October 2019}}</ref> Studies are being undertaken to understand the links in breeding and the disorder.<ref>{{cite web |url=http://www.cvm.ncsu.edu/vhc/csds/vcgl/ |title=Sphynx HCM Research |publisher=North Carolina State University school of veterinary medicine |access-date=1 February 2013 |archive-date=18 June 2015 |archive-url=https://web.archive.org/web/20150618081358/http://www.cvm.ncsu.edu/vhc/csds/vcgl/ |url-status=dead }}</ref> Cats are screened for HCM disease with [[echocardiography]] (ultrasound of the heart), as well as with additional tests determined by the veterinarian cardiologist including [[Electrocardiography|electrocardiogram]] (EKG, ECG), [[chest radiograph]]s (X-rays), and/or blood tests.<ref name=":9" /> The Sphynx cat has a high rate of heart disease, either as HCM or [[mitral valve dysplasia]]. In a 2012 study of 114 Sphynx cats, 34% were found to have an abnormal heart, with 16 cats having mitral valve dysplasia and 23 cats having HCM.<ref>{{cite journal |last1=Chetboul |first1=V. |last2=Petit |first2=A. |last3=Gouni |first3=V. |last4=Trehiou-Sechi |first4=E. |last5=Misbach |first5=C. |last6=Balouka |first6=D. |last7=Carlos Sampedrano |first7=C. |last8=Pouchelon |first8=J. L. |last9=Tissier |first9=R. |last10=Abitbol |first10=M. |title=Prospective echocardiographic and tissue Doppler screening of a large Sphynx cat population: Reference ranges, heart disease prevalence and genetic aspects |journal=Journal of Veterinary Cardiology |date=December 2012 |volume=14 |issue=4 |pages=497β509 |doi=10.1016/j.jvc.2012.08.001 |pmid=23131204|doi-access=free }}</ref> These prevalences were found in cats with an average age of 2.62 years. Male cats developed more severe disease than female cats and often developed it earlier, at an average age of 19 months for males and 29 months for females.<ref name=":8" /> Since the prevalence of genetic heart disease is high in this breed, many breeders will recommend screening for HCM yearly. As HCM progresses into an advanced stage, cats may experience [[Heart failure|congestive heart failure]] (CHF) or [[Venous thrombosis|thromboembolism]].<ref name=":9" />
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