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==Clinical significance== {{See also|Gastrointestinal disease}} The small intestine is a complex organ, and as such, there are a very large number of possible conditions that may affect the function of the small bowel. A few of them are listed below, some of which are common, with up to 10% of people being affected at some time in their lives, while others are vanishingly rare. {{Div col}} * Small intestine obstruction or obstructive disorders ** [[Meconium ileus]] ** Paralytic [[ileus]] ** [[Volvulus]] ** [[Hernia]] ** [[Intussusception (medical disorder)|Intussusception]] ** [[Adhesions]] ** Obstruction from external pressure ** Obstruction by masses in the lumen ([[foreign body|foreign bodies]], [[bezoar]], [[gallstone]]s) * [[Infectious diseases]] ** [[Giardiasis]] ** [[Ascariasis]] ** [[Tropical sprue]] ** Tapeworm (''[[Diphyllobothrium latum]]'', ''[[Taenia solium]]'', ''[[Hymenolepis nana]]'') ** Hookworm (e.g. ''[[Necator americanus]]'', ''[[Ancylostoma duodenale]]'') ** Nematodes (e.g. ''[[Ascaris lumbricoides]]'') ** Other Protozoa (e.g. ''[[Cryptosporidium parvum]]'', ''[[Cyclospora]]'', ''[[Microsporidia]]'', ''[[Entamoeba histolytica]]'') ** Bacterial infections *** Enterotoxigenic ''[[Escherichia coli]]'' *** ''[[Salmonella enterica]]'' *** ''[[Campylobacter]]'' *** ''[[Shigella]]'' *** ''[[Yersinia]]'' *** ''[[Clostridioides difficile infection|Clostridioides difficile]]'' (antibiotic-associated colitis, ''[[Pseudomembranous colitis]]'') *** ''[[Mycobacterium]]'' ([[Mycobacterium avium paratuberculosis]], disseminated ''[[Mycobacterium tuberculosis]]'') *** [[Whipple's disease]] *** ''[[Vibrio]]'' ([[cholera]]) *** [[Typhoid|Enteric (typhoid) fever]] (''[[Salmonella enterica]]'' var. typhii) and [[paratyphoid fever]] *** ''[[Bacillus cereus]]'' *** ''[[Clostridium perfringens]]'' ([[gas gangrene]]) ** Viral infections *** [[Rotavirus]] *** [[Norovirus]] *** [[Astrovirus]] *** [[Adenovirus]] *** [[Calicivirus]] * [[Neoplasm]]s (cancers) ** [[Adenocarcinoma]] ** [[Carcinoid]] ** [[Gastrointestinal stromal tumor]] (GIST) ** [[Lymphoma]] ** [[Sarcoma]] ** [[Leiomyoma]] ** Metastatic tumors, especially [[Small cell carcinoma|SCLC]] or [[melanoma]] ** [[Small intestine cancer]] * Developmental, congenital or genetic conditions ** [[Intestinal atresia|Duodenal (intestinal) atresia]] ** [[Hirschsprung's disease]] ** [[Meckel's diverticulum]] ** [[Pyloric stenosis]] ** [[Pancreas divisum]] ** [[Ectopic pancreas]] ** [[Enteric duplication cyst]] ** [[Situs inversus]] ** [[Cystic fibrosis]] ** Malrotation ** Persistent [[urachus]] ** [[Omphalocele]] ** [[Gastroschisis]] ** [[Disaccharidase]] ([[lactase]]) deficiencies ** Primary [[bile acid malabsorption]] ** [[Gardner syndrome]] ** [[Familial adenomatous polyposis]] syndrome (FAP) * Other conditions ** [[Crohn's disease]], and the more general [[inflammatory bowel disease]] ** [[Typhlitis]] ([[neutropenic]] [[colitis]] in the [[immunosuppressed]] ** [[Coeliac disease]] (sprue or non-tropical sprue) ** [[Mesenteric ischemia]] ** [[Embolus]] or [[thrombus]] of the [[superior mesenteric artery]] or the [[superior mesenteric vein]] ** [[Arteriovenous malformation]] ** [[Gastric dumping syndrome]] ** [[Irritable bowel syndrome]] ** [[Peptic ulcer|Duodenal (peptic) ulcers]] ** [[Gastrointestinal perforation]] ** [[Hyperthyroidism]] ** [[Diverticulitis]] ** [[Radiation enterocolitis]] ** [[Mesenteric cyst]]s ** [[Peritoneal]] Infection ** [[Sclerosing]] [[retroperitonitis]] ** [[Small intestinal bacterial overgrowth]] ** [[Endometriosis]] {{Div col end}}
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