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===Sexual=== Like other SSRIs, sertraline is associated with sexual side effects, including [[sexual arousal disorder]], [[erectile dysfunction]] and difficulty achieving [[orgasm]]. While [[nefazodone]] and [[bupropion]] do not have negative effects on sexual functioning, 67% of men on sertraline experienced ejaculation difficulties versus 18% before the treatment.<ref name="pmid11229450">{{cite journal | vauthors = Ferguson JM | title = The effects of antidepressants on sexual functioning in depressed patients: a review | journal = The Journal of Clinical Psychiatry | volume = 62 | issue = Suppl 3 | pages = 22β34 | year = 2001 | pmid = 11229450 | series = 62 }}</ref> [[Sexual arousal]] disorder, defined as "inadequate lubrication and swelling for women and erectile difficulties for men", occurred in 12% of people on sertraline as compared with 1% of patients on placebo. The mood improvement resulting from the treatment with sertraline sometimes counteracted these side effects, so that [[sexual desire]] and overall satisfaction with sex stayed the same as before the sertraline treatment. However, under the action of placebo the desire and satisfaction slightly improved.<ref name="pmid10363731">{{cite journal | vauthors = Croft H, Settle E, Houser T, Batey SR, Donahue RM, Ascher JA | title = A placebo-controlled comparison of the antidepressant efficacy and effects on sexual functioning of sustained-release bupropion and sertraline | journal = Clinical Therapeutics | volume = 21 | issue = 4 | pages = 643β58 | date = April 1999 | pmid = 10363731 | doi = 10.1016/S0149-2918(00)88317-4 }}</ref> Some people continue experiencing sexual side effects after they stop taking SSRIs.<ref>{{cite journal | vauthors = Bala A, Nguyen HM, Hellstrom WJ | title = Post-SSRI Sexual Dysfunction: A Literature Review | journal = Sexual Medicine Reviews | volume = 6 | issue = 1 | pages = 29β34 | date = January 2018 | pmid = 28778697 | doi = 10.1016/j.sxmr.2017.07.002 }}</ref>
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