Editing Salvinorin A (section)

== Associated compounds ==
{{Main|Salvinorin}}

Salvinorin A is one of several structurally related salvinorins found in the ''Salvia divinorum'' plant. Salvinorin A is the only naturally occurring salvinorin that is known to be psychoactive.<ref name=Munro2003/> Salvinorin&nbsp;A can be synthesized from salvinorin B by [[acetylation]], and de-[[acetyl]]ated salvinorin&nbsp;A becomes analog to salvinorin&nbsp;B.<ref name="lee2005a">{{cite journal | vauthors = Lee DY, Karnati VV, He M, Liu-Chen LY, Kondaveti L, Ma Z, Wang Y, Chen Y, Beguin C, Carlezon WA, Cohen B | display-authors = 6 | title = Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues | journal = Bioorganic & Medicinal Chemistry Letters | volume = 15 | issue = 16 | pages = 3744–3747 | date = August 2005 | pmid = 15993589 | doi = 10.1016/j.bmcl.2005.05.048 }}</ref>

Research has produced a number of [[semi-synthetic]] compounds. Most derivatives are selective kappa opioid agonists as with salvinorin&nbsp;A, although some are even more potent, with the most potent compound salvinorin&nbsp;B ethoxymethyl ether being ten times stronger than salvinorin&nbsp;A. Some derivatives, such as [[herkinorin]], reduce kappa opioid action and instead act as [[Mu opioid receptor|mu opioid]] agonists.<ref name=Munro2008/><ref name=Holden2007/><ref name=Lee2006/><ref name=Beguin2006/>

The synthetic derivative [[RB-64]] is notable because of its [[functional selectivity]] and potency.<ref name="pmid25320048">{{cite journal | vauthors = White KL, Robinson JE, Zhu H, DiBerto JF, Polepally PR, Zjawiony JK, Nichols DE, Malanga CJ, Roth BL | display-authors = 6 | title = The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 352 | issue = 1 | pages = 98–109 | date = January 2015 | pmid = 25320048 | pmc = 4279099 | doi = 10.1124/jpet.114.216820 }}</ref> [[Salvinorin B methoxymethyl ether]] is seven times more potent than salvinorin&nbsp;A at KOPr in GTP-γS assays.<ref>{{cite journal | vauthors = Wang Y, Chen Y, Xu W, Lee DY, Ma Z, Rawls SM, Cowan A, Liu-Chen LY | display-authors = 6 | title = 2-Methoxymethyl-salvinorin B is a potent kappa opioid receptor agonist with longer lasting action in vivo than salvinorin A | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 324 | issue = 3 | pages = 1073–1083 | date = March 2008 | pmid = 18089845 | pmc = 2519046 | doi = 10.1124/jpet.107.132142 }}</ref>