Editing Rotavirus (section)

=== Specific responses ===
Rotaviruses elicit both B and T cell immune responses. Antibodies to the rotavirus VP4 and VP7 proteins neutralise viral infectivity ''in vitro'' and ''in vivo''.<ref name="pmid19252425">{{cite journal |vauthors=Ward R |title=Mechanisms of protection against rotavirus infection and disease |journal=The Pediatric Infectious Disease Journal |volume=28 |issue=Suppl 3 |pages=S57–S59 |year=2009 |pmid=19252425 |doi=10.1097/INF.0b013e3181967c16 |doi-access=free }}</ref> Specific antibodies of the classes IgM, IgA and IgG are produced, which have been shown to protect against rotavirus infection by the passive transfer of the antibodies in other animals.<ref name="pmid22880110">{{cite journal |vauthors=Vega CG, Bok M, Vlasova AN, Chattha KS, Fernández FM, Wigdorovitz A, Parreño VG, Saif LJ |title=IgY antibodies protect against human Rotavirus induced diarrhea in the neonatal gnotobiotic piglet disease model |journal=PLOS ONE |volume=7 |issue=8 |pages=e42788 |year=2012 |pmid=22880110 |pmc=3411843 |doi=10.1371/journal.pone.0042788 |bibcode=2012PLoSO...742788V |doi-access=free }}</ref> Maternal trans-placental IgG might play a role in the protection neonates from rotavirus infections, but on the other hand might reduce vaccine efficacy.<ref name="pmid27847365">{{cite journal |vauthors=Mwila K, Chilengi R, Simuyandi M, Permar SR, Becker-Dreps S |title=Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries |journal=Clinical and Vaccine Immunology |volume=24 |issue=1 |year=2017 |pmid=27847365 |pmc=5216432 |doi=10.1128/CVI.00405-16 }}</ref>