Editing Reelin (section)

=== Interaction with Cdk5 ===
[[Cyclin-dependent kinase 5]] (Cdk5), a major regulator of neuronal migration and positioning, is known to phosphorylate [[DAB1]]<ref name="pmid14645539" /><ref name="pmid16529723" /><ref name="pmid12077184" /> and other cytosolic targets of reelin signaling, such as [[Tau protein|Tau]],<ref name="pmid8253190" /> which could be activated also via reelin-induced deactivation of [[GSK3B]],<ref name="pmid12376533" /> and [[NDEL1|NUDEL]],<ref name="pmid11163259" /> associated with [[PAFAH1B1|Lis1]], one of the DAB1 targets. [[Long-term potentiation|LTP]] induction by reelin in hippocampal slices fails in [[CDK5R1|p35]] knockouts.<ref name="pmid14985430" /> P35 is a key Cdk5 activator, and double p35/Dab1, p35/RELN, p35/ApoER2, p35/VLDLR knockouts display increased neuronal migration deficits,<ref name="pmid14985430" /><ref name="pmid11226314" /> indicating a synergistic action of reelin → ApoER2/VLDLR → DAB1 and p35/p39 → Cdk5 pathways in the normal corticogenesis.