Editing RNA splicing (section)

==Role of nuclear speckles in RNA splicing==

The location of pre-mRNA splicing is throughout the nucleus, and once mature mRNA is generated, it is transported to the cytoplasm for translation. In both plant and animal cells, [[nuclear speckles]] are regions with high concentrations of splicing factors. These speckles were once thought to be mere storage centers for splicing factors. However, it is now understood that nuclear speckles help concentrate splicing factors near genes that are physically located close to them. Genes located farther from speckles can still be transcribed and spliced, but their splicing is less efficient compared to those closer to speckles. Cells can vary their genomic positions of genes relative to nuclear speckles as a mechanism to modulate the expression of genes via splicing. <ref>{{cite journal | vauthors = Bhat P, Chow A, Emert B et al | title = Genome organization around nuclear speckles drives mRNA splicing efficiency. | journal = Nature | volume = 629 | issue = 5 | pages = 1165–1173 | date = May 2024 | pmid = 38720076 | pmc = 11164319 | doi = 10.1038/s41586-024-07429-6 | bibcode = 2024Natur.629.1165B }}</ref>