Editing Quorum sensing (section)

====''Salmonella enterica''====
''[[Salmonella]]'' encodes a LuxR homolog, SdiA, but does not encode an AHL synthase. SdiA detects AHLs produced by other species of bacteria including ''[[Aeromonas hydrophila]]'', ''[[Hafnia alvei]]'', and ''[[Yersinia enterocolitica]]''.<ref>{{cite journal | vauthors = Michael B, Smith JN, Swift S, Heffron F, Ahmer BM | title = SdiA of Salmonella enterica is a LuxR homolog that detects mixed microbial communities | journal = Journal of Bacteriology | volume = 183 | issue = 19 | pages = 5733–5742 | date = October 2001 | pmid = 11544237 | pmc = 95466 | doi = 10.1128/JB.183.19.5733-5742.2001 }}</ref> When AHL is detected, SdiA regulates the ''rck'' operon on the ''Salmonella'' virulence plasmid (''pefI-srgD-srgA-srgB-rck-srgC'') and a single gene horizontal acquisition in the chromosome ''srgE''.<ref>{{cite journal | vauthors = Ahmer BM, van Reeuwijk J, Timmers CD, Valentine PJ, Heffron F | title = Salmonella typhimurium encodes an SdiA homolog, a putative quorum sensor of the LuxR family, that regulates genes on the virulence plasmid | journal = Journal of Bacteriology | volume = 180 | issue = 5 | pages = 1185–1193 | date = March 1998 | pmid = 9495757 | pmc = 107006 | doi = 10.1128/JB.180.5.1185-1193.1998 }}</ref><ref>{{cite journal | vauthors = Smith JN, Ahmer BM | title = Detection of other microbial species by Salmonella: expression of the SdiA regulon | journal = Journal of Bacteriology | volume = 185 | issue = 4 | pages = 1357–1366 | date = February 2003 | pmid = 12562806 | pmc = 142872 | doi = 10.1128/JB.185.4.1357-1366.2003 }}</ref> ''Salmonella'' does not detect AHL when passing through the gastrointestinal tracts of several animal species, suggesting that the normal microbiota does not produce AHLs. However, SdiA does become activated when ''Salmonella'' transits through turtles colonized with ''Aeromonas hydrophila'' or mice infected with ''Yersinia enterocolitica''.<ref>{{cite journal | vauthors = Smith JN, Dyszel JL, Soares JA, Ellermeier CD, Altier C, Lawhon SD, Adams LG, Konjufca V, Curtiss R, Slauch JM, Ahmer BM | display-authors = 6 | title = SdiA, an N-acylhomoserine lactone receptor, becomes active during the transit of Salmonella enterica through the gastrointestinal tract of turtles | journal = PLOS ONE | volume = 3 | issue = 7 | pages = e2826 | date = July 2008 | pmid = 18665275 | pmc = 2475663 | doi = 10.1371/journal.pone.0002826 | bibcode = 2008PLoSO...3.2826S | doi-access = free | editor = Ausubel, Frederick M. }}</ref><ref>{{cite journal | vauthors = Dyszel JL, Smith JN, Lucas DE, Soares JA, Swearingen MC, Vross MA, Young GM, Ahmer BM | display-authors = 6 | title = Salmonella enterica serovar Typhimurium can detect acyl homoserine lactone production by Yersinia enterocolitica in mice | journal = Journal of Bacteriology | volume = 192 | issue = 1 | pages = 29–37 | date = January 2010 | pmid = 19820103 | pmc = 2798265 | doi = 10.1128/JB.01139-09 }}</ref> Therefore, ''Salmonella'' appears to use SdiA to detect the AHL production of other pathogens rather than the normal gut flora.